Evidence map›Paper›PMID 29562936›Full record

ArticleMicrobiome2018

Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier.

Lesley Hoyles, Tom Snelling, Umm-Kulthum Umlai, Jeremy K Nicholson, Simon R Carding, Robert C Glen, Simon McArthur

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 340 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
340citing papers in PubMed, 5 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

340 citing papers in PubMed, 5 syntheses or guidelines pooled it, 552 citations in OpenAlex.

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280 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Lesley HoylesDivision of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, London, UK. lesley.hoyles11@imperial.ac.uk.
Tom SnellingDivision of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, London, UK.
Umm-Kulthum UmlaiDivision of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, London, UK.
Jeremy K NicholsonDivision of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, London, UK.
Simon R CardingNorwich Medical School, University of East Anglia, Norwich, UK.
Robert C GlenDivision of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, London, UK.
Simon McArthurInstitute of Dentistry, Barts and the London School of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK. s.mcarthur@qmul.ac.uk.ORCID 0000-0001-8521-1808
Imperial College London · GBQueen Mary University of London · GBUniversity of Cambridge · GBUniversity of East Anglia · GB

Funding

Alzheimer's Research UK ARUK-PPG2016B-6Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10353Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10355Medical Research Council MR/L01632X/1
6 · The paper itself

Abstract

backgroundGut microbiota composition and function are symbiotically linked with host health and altered in metabolic, inflammatory and neurodegenerative disorders. Three recognised mechanisms exist by which the microbiome influences the gut-brain axis: modification of autonomic/sensorimotor connections, immune activation, and neuroendocrine pathway regulation. We hypothesised interactions between circulating gut-derived microbial metabolites, and the blood-brain barrier (BBB) also contribute to the gut-brain axis. Propionate, produced from dietary substrates by colonic bacteria, stimulates intestinal gluconeogenesis and is associated with reduced stress behaviours, but its potential endocrine role has not been addressed.

resultsAfter demonstrating expression of the propionate receptor FFAR3 on human brain endothelium, we examined the impact of a physiologically relevant propionate concentration (1 μM) on BBB properties in vitro. Propionate inhibited pathways associated with non-specific microbial infections via a CD14-dependent mechanism, suppressed expression of LRP-1 and protected the BBB from oxidative stress via NRF2 (NFE2L2) signalling.

conclusionsTogether, these results suggest gut-derived microbial metabolites interact with the BBB, representing a fourth facet of the gut-brain axis that warrants further attention.

Indexed as

BacteriaBlood-Brain BarrierCells, CulturedGastrointestinal MicrobiomeGastrointestinal TractGluconeogenesisHumansLow Density Lipoprotein Receptor-Related Protein-1MetabolomeNF-E2-Related Factor 2Oxidative StressPropionatesReceptors, G-Protein-CoupledSignal TransductionFFAR3 protein, humanLDLR-related protein 1A, humanLow Density Lipoprotein Receptor-Related Protein-1NFE2L2 protein, humanNF-E2-Related Factor 2PropionatesReceptors, G-Protein-Coupled

Identifiers

PMID29562936
PMCPMC5863458
OpenAlexW2951463045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.