Evidence map›Paper›PMID 29562774›Full record

ArticleCell transplantation2018

Xenograft of Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly Differentiating into Osteocytes and Reducing Osteoclast Activity Reverses Osteoporosis in Ovariectomized Rats.

Yu-Show Fu, Chia-Hui Lu, Kuo-An Chu, Chang-Ching Yeh, Tung-Lin Chiang, Tsui-Ling Ko, Mei-Miao Chiu, Cheng-Fong Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Yu-Show Fu1 Department of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.
Chia-Hui Lu3 Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.
Kuo-An Chu4 Department of Internal Medicine, Division of Chest Medicine, Kaohsiung Veterans General Hospital, Taiwan, Republic of China.
Chang-Ching Yeh5 Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.
Tung-Lin Chiang8 Taipei Municipal Jianguo High School, Taipei, Taiwan, Republic of China.
Tsui-Ling Ko9 Department of Optometry, Shu-Zen College of Medicine and Management, Kaohsiung City, Taiwan, Republic of China.
Mei-Miao Chiu9 Department of Optometry, Shu-Zen College of Medicine and Management, Kaohsiung City, Taiwan, Republic of China.
Cheng-Fong Chen11 Department of Orthopaedics and Traumatology, Division of Joint Reconstruction, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.
Min-Hwei College of Health Care Management · TWNational Yang Ming Chiao Tung University · TWKaohsiung Veterans General Hospital · TWTaipei City Hospital · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined the effects of human umbilical cord-derived mesenchymal stem cells (HUMSCs) in Wharton's jelly on ovariectomy (OVX)-induced osteoporosis by using in vitro and in vivo experiments. Two months after OVX, the rats gained weight and had a decreased serum estradiol level . Both micro-computed tomography (micro-CT) and histochemical analyses revealed a marked decrease in the bone volume (BV) and collagen content within the head, neck, and distal condyle of the femur, indicating that the osteoporosis animal model was successfully established 2 mo after bilateral OVX. Subsequently, 2.5 × 10

Indexed as

AnimalsCell DifferentiationFemaleHumansMesenchymal Stem CellsOsteoblastsOsteoclastsOsteocytesOsteoporosisRatsWharton Jellyosteoblastosteoclastosteoporosisumbilical cord-derived mesenchymal stem cellsWharton’s jellyxenograft

Identifiers

PMID29562774
PMCPMC6434481
OpenAlexW2791877887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.