Evidence map›Paper›PMID 29562716›Full record

ReviewInternational journal of molecular sciences2018

Amino Acid Metabolism and Transport Mechanisms as Potential Antifungal Targets.

Matthew W McCarthy, Thomas J Walsh

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Antifungal conjugates incorporating NScientific reports · 2026
    Article
  2. Transcriptomic analysis ofFrontiers in fungal biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Antifungal activity against Candida albicans of methyl 3,5-dinitrobenzoate loaded nanoemulsion.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  10. Article
  11. A Limited Number of Amino Acid Permeases Are Crucial forInternational journal of microbiology · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Aspergillus fumigatus and Aspergillosis in 2019.Clinical microbiology reviews · 2019
    Review
  18. Article
  19. Vitamin Biosynthesis as an Antifungal Target.Journal of fungi (Basel, Switzerland) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthew W McCarthyDepartments of Medicine, Weill Cornell Medicine of Cornell University, New York, NY 10065, USA. mwm9004@med.cornell.edu.
Thomas J WalshDepartments of Medicine, Weill Cornell Medicine of Cornell University, New York, NY 10065, USA. thw2003@med.cornell.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Discovering new drugs for treatment of invasive fungal infections is an enduring challenge. There are only three major classes of antifungal agents, and no new class has been introduced into clinical practice in more than a decade. However, recent advances in our understanding of the fungal life cycle, functional genomics, proteomics, and gene mapping have enabled the identification of new drug targets to treat these potentially deadly infections. In this paper, we examine amino acid transport mechanisms and metabolism as potential drug targets to treat invasive fungal infections, including pathogenic yeasts, such as species of

Indexed as

Amino AcidsAmino Acid Transport SystemsAnimalsAntifungal AgentsBiological TransportDrug Delivery SystemsDrug DiscoveryHumansAmino AcidsAmino Acid Transport SystemsAntifungal Agentsamino acid transportersantifungal targetscispentacinicofungipenmetabolismsinefungin

Identifiers

PMID29562716
PMCPMC5877770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.