Evidence map›Paper›PMID 29562710›Full record

ArticleMolecules (Basel, Switzerland)2018

Molecular Modeling and Structural Stability of Wild-Type and Mutant CYP51 from Leishmania major: In Vitro and In Silico Analysis of a Laboratory Strain.

Masoud Keighobadi, Saeed Emami, Milad Lagzian, Mahdi Fakhar, Alireza Rafiei, Reza Valadan

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Characterization ofAnimals : an open access journal from MDPI · 2023
    Article
  3. Article
  4. Unravelling the myth surrounding sterol biosynthesis as plausible target for drug design against leishmaniasis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Masoud KeighobadiPharmaceutical Sciences Research Center, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran. keighobadi216@yahoo.com.
Saeed EmamiDepartment of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, 48157-33971, Iran. sd_emami@yahoo.com.ORCID 0000-0003-1665-6621
Milad LagzianDepartment of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan 98168-76578, Iran. m.lagzian@science.usb.ac.ir.
Mahdi FakharDepartment of Parasitology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran. mahdif53@yahoo.com.
Alireza RafieiMolecular and Cell Biology Research Center (MCBRC), Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran. rafiei1710@gmail.com.
Reza ValadanMolecular and Cell Biology Research Center (MCBRC), Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 48157-33971, Iran. rvaladan@mazums.ac.ir.ORCID 0000-0002-9074-6994
Mazandaran University of Medical Sciences · IRUniversity of Sistan and Baluchestan · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous leishmaniasis is a neglected tropical disease and a major public health in the most countries.

Indexed as

Computer SimulationModels, MolecularAmino Acid SequenceBase SequenceCytochrome P450 Family 51Enzyme StabilityLeishmania majorMolecular Dynamics SimulationMutant ProteinsMutationPhylogenyProtein Structure, SecondaryStructural Homology, ProteinTemperatureTime FactorsCytochrome P450 Family 51Mutant Proteinshomology modelinglanosterol 14α-demethylaseLeishmania majormolecular dynamicsmutationprotein stability

Identifiers

PMID29562710
PMCPMC6017637
OpenAlexW2790739417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.