ArticleInternational journal of environmental research and public health2018
Sex-Specific Association between Metabolic Abnormalities and Elevated Alanine Aminotransferase Levels in a Military Cohort: The CHIEF Study.
Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 42 citations in OpenAlex.
- Relationship between monocyte-to-HDL-cholesterol ratio, estradiol levels, and coronary atherosclerosis severity in postmenopausal women.BMC cardiovascular disorders · 2025Article
- Risk of Insulin Resistance in 44,939 Spanish Healthcare Workers: Association with Sociodemographic Variables and Healthy Habits.Diseases (Basel, Switzerland) · 2025Article
- Early risk detection of metabolic syndrome using sex-specific machine learning models in military personnel.Frontiers in public health · 2025Article
- Plasma Hepatic Transaminases and Incidence of Metabolic Syndrome Before Midlife in Military Adults: A CHIEF Cohort Study.Endocrine, metabolic & immune disorders drug targets · 2025Article
- Nutritional impact of nano zeolite, probiotic, and fatty acids as feed additives on health status of Nile tilapia (Oreochromis niloticus).Scientific reports · 2023Article
- Prevalence and metabolic determinants of abnormal alanine aminotransferase: A cross-sectional study of Iranian adults, 2018-2022.Journal of clinical laboratory analysis · 2023Article
- Sex differences in risk factors for metabolic syndrome in middle-aged and senior hospital employees: a population-based cohort study.BMC public health · 2023Article
- Moderate or greater daily coffee consumption is associated with lower incidence of metabolic syndrome in Taiwanese militaries: results from the CHIEF cohort study.Frontiers in nutrition · 2023Article
- The influence of demographic and lifestyle factors on blood donation delay among student population: a retrospective study.Frontiers in public health · 2023Article
- Alanine aminotransferase to aspartate aminotransferase ratio and hepatitis B virus on metabolic syndrome: a community-based study.Frontiers in endocrinology · 2022Article
- Metabolic Syndrome and Its Related Factors among Hospital Employees: A Population-Based Cohort Study.International journal of environmental research and public health · 2021Article
- Metabolically healthy obesity and physical fitness in military males in the CHIEF study.Scientific reports · 2021Article
- Prevalence and characteristics of mitral valve prolapse in military young adults in Taiwan of the CHIEF Heart Study.Scientific reports · 2021Article
- Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study.BMC cardiovascular disorders · 2021Article
- Factors associated with elevated alanine aminotransferase in employees of a German chemical company: results of a large cross-sectional study.BMC gastroenterology · 2021Article
- Comparison of ultrasound guided versus CT guided radiofrequency ablation on liver function, serum PIVKA-II, AFP levels and recurrence in patients with primary hepatocellular carcinoma.American journal of translational research · 2021Article
- Article
- Association of Liver Transaminase Levels and Long-Term Blood Pressure Variability in Military Young Males: The CHIEF Study.International journal of environmental research and public health · 2020Article
- Association of Single Measurement of dipstick proteinuria with physical performance of military males: the CHIEF study.BMC nephrology · 2020Article
- Metabolic biomarkers and long-term blood pressure variability in military young male adults.World journal of clinical cases · 2020Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association of metabolic syndrome (MetS) components with elevated serum alanine aminotransferase (ALT) levels, a marker of hepatic injury, may differ between men and women. However, the sex-specific association in a military young population which has a low prevalence of MetS was unclear. We conducted a cross-sectional examination in 6738 men and 766 women, aged 18-50 years, from the cardiorespiratory fitness study in armed forces (CHIEF) in eastern Taiwan. The components of MetS were defined according to the updated International Diabetes Federation (IDF) ethnic criteria for Asians. Elevated ALT levels were defined as ≥40 U/L for both sexes and ≥30 U/L for women alternatively. Multivariate logistic regression analysis was performed to determine the sex-specific association between MetS components and elevated ALT. The prevalence of MetS and elevated ALT in men were 11.9% and 12.7% respectively, and in women were 3.5%, and 3.8% respectively. In men, high-density lipoprotein < 40 mg/dL, blood pressures ≥ 130/85 mmHg, serum triglycerides ≥ 150 mg/dL, and waist size ≥ 90 cm were associated with elevated ALT (odds ratios (OR) and 95% confidence intervals: 1.59 (1.34-1.90), 1.40 (1.19-1.65), 2.00 (1.68-2.39), and 1.68 (1.38-2.04); all
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