Evidence map›Paper›PMID 29562669›Full record

ArticleNanomaterials (Basel, Switzerland)2018

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity.

Alaa A A Aljabali, Yazan Akkam, Mazhar Salim Al Zoubi, Khalid M Al-Batayneh, Bahaa Al-Trad, Osama Abo Alrob, Alaaldin M Alkilany, Mourad Benamara, David J Evans

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Gold nanoparticles fromResearch in pharmaceutical sciences · 2025
    Article
  10. Antibiotics (Basel, Switzerland) · 2025
    Article
  11. Advanced biomedical research · 2025
    Article
  12. Green Synthesis of Metallic Nanoparticles fromAntioxidants (Basel, Switzerland) · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. UV-Vis detection ofMethodsX · 2024
    Article
  17. Food science & nutrition · 2024
    Article
  18. Article
  19. Plant-mediated green synthesis of gold nanoparticles using an aqueous extract ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alaa A A AljabaliFaculty of Pharmacy, Yarmouk University, P.O.BOX 566, Irbid 21163, Jordan. alaaj@yu.edu.jo.ORCID 0000-0002-9519-6338
Yazan AkkamFaculty of Pharmacy, Yarmouk University, P.O.BOX 566, Irbid 21163, Jordan. yazan.a@yu.edu.jo.
Mazhar Salim Al ZoubiDepartment of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid 21163, Jordan. mszoubi@yu.edu.jo.ORCID 0000-0003-0248-4777
Khalid M Al-BataynehDepartment of Biological Science, Yarmouk University, P.O.BOX 566, Irbid 21163, Jordan. albatynehk@yu.edu.jo.
Bahaa Al-TradDepartment of Biological Science, Yarmouk University, P.O.BOX 566, Irbid 21163, Jordan. bahaa.tr@yu.edu.jo.ORCID 0000-0002-2062-6241
Osama Abo AlrobFaculty of Pharmacy, Yarmouk University, P.O.BOX 566, Irbid 21163, Jordan. osama.yousef@yu.edu.jo.
Alaaldin M AlkilanySchool of Pharmacy, University of Jordan, Aljubeiha, Amman, Jordan 11942, Jordan. a.alkilany@ju.edu.jo.
Mourad BenamaraInstitute for Nanoscience, University of Arkansas, Fayetteville, AR 72701, USA. mourad@uark.edu.
David J EvansJohn Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Dave.Evans@jic.ac.uk.ORCID 0000-0002-6290-2849

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: There is a growing need for the development of new methods for the synthesis of nanoparticles. The interest in such particles has raised concerns about the environmental safety of their production methods; (2) Objectives: The current methods of nanoparticle production are often expensive and employ chemicals that are potentially harmful to the environment, which calls for the development of "greener" protocols. Herein we describe the synthesis of gold nanoparticles (AuNPs) using plant extracts, which offers an alternative, efficient, inexpensive, and environmentally friendly method to produce well-defined geometries of nanoparticles; (3) Methods: The phytochemicals present in the aqueous leaf extract acted as an effective reducing agent. The generated AuNPs were characterized by Transmission electron microscopy (TEM), Scanning electron microscope (SEM), and Atomic Force microscopy (AFM), X-ray diffraction (XRD), UV-visible spectroscopy, energy dispersive X-ray (EDX), and thermogravimetric analyses (TGA); (4) Results and Conclusions: The prepared nanoparticles were found to be biocompatible and exhibited no antimicrobial or antifungal effect, deeming the particles safe for various applications in nanomedicine. TGA analysis revealed that biomolecules, which were present in the plant extract, capped the nanoparticles and acted as stabilizing agents.

Indexed as

antifungal activitybiopharmaceuticsbiosynthesisgold nanoparticlesgreen chemistrynanomaterialsZiziphus zizyphus

Identifiers

PMID29562669
PMCPMC5869665

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.