Evidence map›Paper›PMID 29562656›Full record

ArticleInternational journal of molecular sciences2018

Evaluation of Promoter Methylation of RASSF1A and ATM in Peripheral Blood of Breast Cancer Patients and Healthy Control Individuals.

Xue Cao, Qiuqiong Tang, Tim Holland-Letz, Melanie Gündert, Katarina Cuk, Sarah Schott, Jörg Heil, Michael Golatta, Christof Sohn, Andreas Schneeweiss and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  11. Epigenetic heterogeneity in cancer.Biomarker research · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xue CaoMolecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg 69120, Germany. cxuecmu@outlook.com.
Qiuqiong TangMolecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg 69120, Germany. tangqiuqiong2017@foxmail.com.
Tim Holland-LetzDivision of Biostatistics (C060), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. t.holland-letz@Dkfz-Heidelberg.de.
Melanie GündertMolecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg 69120, Germany. melanie.guendert@t-online.de.ORCID 0000-0003-2236-6604
Katarina CukMolecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg 69120, Germany. k.cuk@Dkfz-Heidelberg.de.
Sarah SchottMolecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg 69120, Germany. Sarah.Schott@med.uni-heidelberg.de.
Jörg HeilDepartment of Gynecology and Obstetrics, University Women's Clinic, Heidelberg 69120, Germany. Joerg.Heil@med.uni-heidelberg.de.
Michael GolattaDepartment of Gynecology and Obstetrics, University Women's Clinic, Heidelberg 69120, Germany. Michael.Golatta@med.uni-heidelberg.de.
Christof SohnMolecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg 69120, Germany. Christof.Sohn@med.uni-heidelberg.de.
Andreas SchneeweissMolecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg 69120, Germany. Andreas.Schneeweiss@med.uni-heidelberg.de.
Barbara BurwinkelMolecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg 69120, Germany. B.Burwinkel@dkfz-heidelberg.de.
German Cancer Research Center · DEHeidelberg University · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is the most common cancer among women and has high mortality rates. Early detection is supposed to be critical for the patient's prognosis. In recent years, several studies have investigated global DNA methylation profiles and gene-specific DNA methylation in blood-based DNA to develop putative screening markers for cancer. However, most of the studies have not yet been validated. In our study, we analyzed the promoter methylation of

Indexed as

Promoter Regions, GeneticAdultAtaxia Telangiectasia Mutated ProteinsBreast NeoplasmsCase-Control StudiesDNA MethylationFemaleHumansMiddle AgedTumor Suppressor ProteinsAtaxia Telangiectasia Mutated ProteinsRASSF1 protein, humanTumor Suppressor ProteinsATMbreast cancerDNA methylationRASSF1A

Identifiers

PMID29562656
PMCPMC5877761
OpenAlexW2793806813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.