Evidence map›Paper›PMID 29562633›Full record

ArticleSensors (Basel, Switzerland)2018

Dielectric Spectroscopy and Optical Density Measurement for the Online Monitoring and Control of Recombinant Protein Production in Stably Transformed Drosophila melanogaster S2 Cells.

Jan Zitzmann, Tobias Weidner, Gerrit Eichner, Denise Salzig, Peter Czermak

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Application ofSensors (Basel, Switzerland) · 2021
    Article
  9. Article
  10. Article
  11. Single-cell cloning enables the selection of more productiveBiotechnology reports (Amsterdam, Netherlands) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jan ZitzmannInstitute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen, Wiesenstrasse 14, 35390 Giessen, Germany. jan.zitzmann@lse.thm.de.ORCID 0000-0003-0971-7094
Tobias WeidnerInstitute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen, Wiesenstrasse 14, 35390 Giessen, Germany. tobias.weidner@lse.thm.de.
Gerrit EichnerMathematical Institute, Justus-Liebig University of Giessen, Arndtstrasse 2, 35392 Giessen, Germany. gerrit.eichner@math.uni-giessen.de.
Denise SalzigInstitute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen, Wiesenstrasse 14, 35390 Giessen, Germany. denise.salzig@lse.thm.de.ORCID 0000-0001-9266-1356
Peter CzermakInstitute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen, Wiesenstrasse 14, 35390 Giessen, Germany. peter.czermak@lse.thm.de.ORCID 0000-0001-7485-500X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The production of recombinant proteins in bioreactors requires real-time process monitoring and control to increase process efficiency and to meet the requirements for a comprehensive audit trail. The combination of optical near-infrared turbidity sensors and dielectric spectroscopy provides diverse system information because different measurement principles are exploited. We used this combination of techniques to monitor and control the growth and protein production of stably transformed

Indexed as

Dielectric SpectroscopyAnimalsBioreactorsCell CountCell LineDrosophila melanogasterRecombinant ProteinsRecombinant Proteinsdielectric spectroscopyDrosophila S2fermentationimpedance spectroscopyoptical density measurementsprocess controlprocess monitoringrecombinant protein production

Identifiers

PMID29562633
PMCPMC5876727

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.