Evidence map›Paper›PMID 29562607›Full record

ArticleBehavioral sciences (Basel, Switzerland)2018

A Cohort Study Comparing Women with Autism Spectrum Disorder with and without Generalized Joint Hypermobility.

Emily L Casanova, Julia L Sharp, Stephen M Edelson, Desmond P Kelly, Manuel F Casanova

Open access · goldAbstract read
In one paragraph

Article in Behavioral sciences (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

  1. Observational
  2. Article
  3. Hypermobile Ehlers-Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Review
  4. Article
  5. Article
  6. Identification of a de novo case ofClinical case reports · 2018
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Emily L CasanovaDepartment of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USA. casanove@greenvillemed.sc.edu.ORCID 0000-0001-5129-6698
Julia L SharpDepartment of Statistics, Colorado State University, Fort Collins, CO 80523, USA. julia.sharp@colostate.edu.
Stephen M EdelsonAutism Research Institute (ARI), San Diego, CA 92116, USA. director@autism.com.
Desmond P KellyDepartment of Pediatrics, Greenville Health System Children's Hospital, Greenville, SC 29605, USA. dkelly@ghs.org.
Manuel F CasanovaDepartment of Biomedical Sciences, University of South Carolina School of Medicine Greenville, Greenville, SC 29605, USA. mcasanova@ghs.org.
Prisma Health · USAutism Research Institute · USColorado State University · US

Funding

Gross morphological correlates to the minicolumnopathy of autismR01HD065279 · NICHD · UNIVERSITY OF LOUISVILLE · PI CASANOVA, MANUEL F · 2009 to 2010
$547k
NICHD NIH HHS R01 HD065279
6 · The paper itself

Abstract

Reports suggest comorbidity between autism spectrum disorder (ASD) and the connective tissue disorder, Ehlers-Danlos syndrome (EDS). People with EDS and the broader spectrum of Generalized Joint Hypermobility (GJH) often present with immune- and endocrine-mediated conditions. Meanwhile, immune/endocrine dysregulation is a popular theme in autism research. We surveyed a group of ASD women with/without GJH to determine differences in immune/endocrine exophenotypes. ASD women 25 years or older were invited to participate in an online survey. Respondents completed a questionnaire concerning diagnoses, immune/endocrine symptom history, experiences with pain, and seizure history. ASD women with GJH (ASD/GJH) reported more immune- and endocrine-mediated conditions than their non-GJH counterparts (

Indexed as

autoimmunityconnective tissue diseasesendocrine system diseaseshumoralimmunitymast cellsneurodevelopmental disorders

Identifiers

PMID29562607
PMCPMC5867488
OpenAlexW2794113188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.