Evidence map›Paper›PMID 29562591›Full record

ReviewNutrients2018

The Western Diet-Microbiome-Host Interaction and Its Role in Metabolic Disease.

Marit K Zinöcker, Inge A Lindseth

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05457439 (Sustainable-psycho-nutritional Intervention Program and Its Effects on Water and Carbon Footprint, Metabolic Biomarkers, and Gut Microbiota in Mexican Population), which is not on this map. Cited by 404 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
404citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05457439 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Sustainable-psycho-nutritional Intervention Program and Its Effects on Water and Carbon Footprint, Metabolic Biomarkers, and Gut Microbiota in Mexican Population: a m-Health Randomized Clinical Trial

TypeinterventionalSponsorUniversity of GuadalajaraRan2022 to 2023Enrolled112ConditionsGut Microbiota, Hyperglycemia, Hypercholesterolemia, HDLCArmsSustainable diet promotion through behavioral change intervention
3 · Its place in the literature

Who cites it

404 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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344 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marit K ZinöckerDepartment of Nutrition, Bjørknes University College, Lovisenberggata 13, 0456 Oslo, Norway. marit.zinocker@bjorkneshoyskole.no.ORCID 0000-0001-8824-0292
Inge A LindsethBalderklinikken, Munchsgate 7, 0165 Oslo, Norway. inge.lindseth@balderklinikken.no.ORCID 0000-0002-6414-4391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dietary pattern that characterizes the Western diet is strongly associated with obesity and related metabolic diseases, but biological mechanisms supporting these associations remain largely unknown. We argue that the Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome. The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease. Recognizing the importance of the microbiome in the development of diet-related disease has implications for future research, public dietary advice as well as food production practices. Research into food patterns suggests that whole foods are a common denominator of diets associated with a low level of diet-related disease. Hence, by studying how ultra-processing changes the properties of whole foods and how these foods affect the gut microbiome, more useful dietary guidelines can be made. Innovations in food production should be focusing on enabling health in the super-organism of man and microbe, and stronger regulation of potentially hazardous components of food products is warranted.

Indexed as

Food HandlingGastrointestinal MicrobiomeAnimalsDiet, WesternFast FoodsFood AdditivesGastrointestinal TractHost-Pathogen InteractionsHumansInflammationMetabolic DiseasesNutritional StatusNutritive ValueRisk FactorsFood Additivesacellular nutrientsadditivesdietary guidelinesfood industryinflammationmetabolic diseasemicrobiomeultra-processed foodwestern dietwhole foods

Identifiers

PMID29562591
PMCPMC5872783

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.