Evidence map›Paper›PMID 29562186›Full record

ArticleCell reports2018

Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion.

Rémi Bos, Ronald M Harris-Warrick, Cécile Brocard, Liliia E Demianenko, Marin Manuel, Daniel Zytnicki, Sergiy M Korogod, Frédéric Brocard

Abstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Machine-Learning Classification of Motor Unit Types in the Adult Mouse.bioRxiv : the preprint server for biology · 2025
    Article
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  8. Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rémi BosInstitut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and Centre National de la Recherche Scientifique (CNRS), Marseille, France.
Ronald M Harris-WarrickDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
Cécile BrocardInstitut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and Centre National de la Recherche Scientifique (CNRS), Marseille, France.
Liliia E DemianenkoBogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine.
Marin ManuelCentre de Neurophysique, Physiologie et Pathologie, UMR 8119, CNRS/Université Paris Descartes, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France.
Daniel ZytnickiCentre de Neurophysique, Physiologie et Pathologie, UMR 8119, CNRS/Université Paris Descartes, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France.
Sergiy M KorogodBogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine.
Frédéric BrocardInstitut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and Centre National de la Recherche Scientifique (CNRS), Marseille, France. Electronic address: frederic.brocard@univ-amu.fr.

Funding

NEUROTRANSMITTERS, NEUROMODULATORS &MOTOR SYSTEMSR01NS017323 · NINDS · CORNELL UNIVERSITY ITHACA · PI HARRIS-WARRICK, RONALD M · 1985 to 2017
$3.3M
Neurotransmitters, Neuromodulators and Motor SystemsR37NS017323 · NINDS · CORNELL UNIVERSITY · PI HARRIS-WARRICK, RONALD M · 2006 to 2012
$2.9M
Neurotransmitters, Neuromodulators and Motor SystemsR56NS017323 · NINDS · CORNELL UNIVERSITY · PI HARRIS-WARRICK, RONALD M · 2013 to 2013
$387k
NINDS NIH HHS R01 NS017323
6 · The paper itself

Abstract

Spinal motoneurons are endowed with nonlinear spiking behaviors manifested by a spike acceleration whose functional significance remains uncertain. Here, we show in rodent lumbar motoneurons that these nonlinear spiking properties do not rely only on activation of dendritic nifedipine-sensitive L-type Ca

Indexed as

Kv1.2 Potassium ChannelLocomotionMotor NeuronsKv1.2 Potassium ChannelbistabilityKv1.2locomotionmotoneuronpotassium channelsspinal cord

Identifiers

PMID29562186
PMCPMC5907934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.