ArticleCell reports2018
C. elegans MRP-5 Exports Vitamin B12 from Mother to Offspring to Support Embryonic Development.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Vitamin BNature communications · 2026Article
- A conserved vesicular circuit enables metabolic adaptation and maintains systemic heme homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Vitamin B12 induces memory of predation through vitellogenin provisioning.Nature communications · 2026Article
- Vitamin BResearch square · 2025Article
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- Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling.Nature communications · 2025Article
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- An improved medium for in vitro studies of female reproduction and oviposition in Schistosoma japonicum.Parasites & vectors · 2024Article
- Notes from the Underground: Heme Homeostasis inBiomolecules · 2023Review
- Dietary-derived vitamin B12 protects Caenorhabditis elegans from thiol-reducing agents.BMC biology · 2022Article
- Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster.BMC biology · 2022Article
- Xenobiotic metabolism and transport inJournal of toxicology and environmental health. Part B, Critical reviews · 2021Review
- Article
- Bacterial vitamin BThe ISME journal · 2020Article
- Vitamin B12 Regulates Glial Migration and Synapse Formation through Isoform-Specific Control of PTP-3/LAR PRTP Expression.Cell reports · 2020Article
- Bacteria increase host micronutrient availability: mechanisms revealed by studies in C. elegans.Genes & nutrition · 2020Review
- The nutritional requirements ofGenes & nutrition · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Vitamin B12 functions as a cofactor for methionine synthase to produce the anabolic methyl donor S-adenosylmethionine (SAM) and for methylmalonyl-CoA mutase to catabolize the short-chain fatty acid propionate. In the nematode Caenorhabditis elegans, maternally supplied vitamin B12 is required for the development of offspring. However, the mechanism for exporting vitamin B12 from the mother to the offspring is not yet known. Here, we use RNAi of more than 200 transporters with a vitamin B12-sensor transgene to identify the ABC transporter MRP-5 as a candidate vitamin B12 exporter. We show that the injection of vitamin B12 into the gonad of mrp-5 deficient mothers rescues embryonic lethality in the offspring. Altogether, our findings identify a maternal mechanism for the transit of an essential vitamin to support the development of the next generation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.