ArticleJournal of the American Chemical Society2018
Single-Molecule Titration in a Protein Nanoreactor Reveals the Protonation/Deprotonation Mechanism of a C:C Mismatch in DNA.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Nanopore Studies of DNA Damage and G-quadruplex Folding in the Human Telomere Sequence.Chimia · 2026Article
- Revealing hidden protonated conformational states in RNA dynamic ensembles.Nucleic acids research · 2025Article
- Localization and discrimination of GG mismatch in duplex DNA by synthetic ligand-enhanced protein nanopore analysis.Nucleic acids research · 2024Article
- Electronic Circuit Simulations as a Tool to Understand Distorted Signals in Single-Entity Electrochemistry.The journal of physical chemistry letters · 2022Article
- Profiling single-molecule reaction kinetics under nanopore confinement.Chemical science · 2022Article
- Stochasticity in Single-Entity Electrochemistry.Current opinion in electrochemistry · 2021Article
- Amplified electrochemical immunoassay for 5-methylcytosine using a nanocomposite prepared from graphene oxide, magnetite nanoparticles and β-cyclodextrin.Mikrochimica acta · 2019Article
- γ-Hemolysin Nanopore Is Sensitive to Guanine-to-Inosine Substitutions in Double-Stranded DNA at the Single-Molecule Level.Journal of the American Chemical Society · 2018Article
- Nanoscale electrochemical kinetics & dynamics: the challenges and opportunities of single-entity measurements.Faraday discussions · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
Measurement of single-molecule reactions can elucidate microscopic mechanisms that are often hidden from ensemble analysis. Herein, we report the acid-base titration of a single DNA duplex confined within the wild-type α-hemolysin (α-HL) nanopore for up to 3 h, while monitoring the ionic current through the nanopore. Modulation between two states in the current-time trace for duplexes containing the C:C mismatch in proximity to the latch constriction of α-HL is attributed to the base flipping of the C:C mismatch. As the pH is lowered, the rate for the C:C mismatch to flip from the intra-helical state to the extra-helical state ( k
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