ArticlePLoS neglected tropical diseases2018
Xenosurveillance reflects traditional sampling techniques for the identification of human pathogens: A comparative study in West Africa.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Xenomonitoring reveals mosquito-host feeding patterns in Serbia.Medical and veterinary entomology · 2026Article
- Mosquito-based xenosurveillance reveals circulation of Anaplasma and Neoehrlichia in livestock at a human-wildlife interface in Kenya.Parasites & vectors · 2026Article
- Seroprevalence of SARS-CoV-2 in rural communities of Burkina faso (West Africa) assessed through blood-fed mosquitoes.Scientific reports · 2026Article
- Molecular xenosurveillance ofMicrobiology spectrum · 2025Article
- Mosquito-based detection of retroviruses and arboviruses in Senegal: expanding the scope of xenosurveillance.One health outlook · 2025Article
- Mosquito bloodmeals can be used to determine vertebrate diversity, host preference, and pathogen exposure in humans and wildlife.Scientific reports · 2024Article
- A virus associated with the zoonotic pathogenbioRxiv : the preprint server for biology · 2024Article
- A metagenomic analysis of the phase 2 Anopheles gambiae 1000 genomes dataset reveals a wide diversity of cobionts associated with field collected mosquitoes.Communications biology · 2024Article
- A virus associated with the zoonotic pathogenVirus evolution · 2024Article
- Evaluation of Vector-Enabled Xenosurveillance in Rural Guatemala.The American journal of tropical medicine and hygiene · 2023Article
- Integrated xenosurveillance of Loa loa, Wuchereria bancrofti, Mansonella perstans and Plasmodium falciparum using mosquito carcasses and faeces: A pilot study in Cameroon.PLoS neglected tropical diseases · 2022Article
- Asynchronicity of endemic and emerging mosquito-borne disease outbreaks in the Dominican Republic.Nature communications · 2021Article
- An Integrated Molecular Approach to Untangling Host-Vector-Pathogen Interactions in Mosquitoes (Diptera: Culicidae) From Sylvan Communities in Mexico.Frontiers in veterinary science · 2020Article
- Stability and detection of nucleic acid from viruses and hosts in controlled mosquito blood feeds.PloS one · 2020Article
- Post-Epidemic Distribution of Schmallenberg Virus inViruses · 2019Article
- Article
- Laboratory evaluation of molecular xenomonitoring using mosquito and tsetse fly excreta/feces to amplifyGates open research · 2019Article
- Use of anthropophilic culicid-based xenosurveillance as a proxy for Plasmodium vivax malaria burden and transmission hotspots identification.PLoS neglected tropical diseases · 2018Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNovel surveillance strategies are needed to detect the rapid and continuous emergence of infectious disease agents. Ideally, new sampling strategies should be simple to implement, technologically uncomplicated, and applicable to areas where emergence events are known to occur. To this end, xenosurveillance is a technique that makes use of blood collected by hematophagous arthropods to monitor and identify vertebrate pathogens. Mosquitoes are largely ubiquitous animals that often exist in sizable populations. As well, many domestic or peridomestic species of mosquitoes will preferentially take blood-meals from humans, making them a unique and largely untapped reservoir to collect human blood. METHODOLOGY/PRINCIPAL
findingsWe sought to take advantage of this phenomenon by systematically collecting blood-fed mosquitoes during a field trail in Northern Liberia to determine whether pathogen sequences from blood engorged mosquitoes accurately mirror those obtained directly from humans. Specifically, blood was collected from humans via finger-stick and by aspirating bloodfed mosquitoes from the inside of houses. Shotgun metagenomic sequencing of RNA and DNA derived from these specimens was performed to detect pathogen sequences. Samples obtained from xenosurveillance and from finger-stick blood collection produced a similar number and quality of reads aligning to two human viruses, GB virus C and hepatitis B virus. CONCLUSIONS/SIGNIFICANCE: This study represents the first systematic comparison between xenosurveillance and more traditional sampling methodologies, while also demonstrating the viability of xenosurveillance as a tool to sample human blood for circulating pathogens.
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Registered trials
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