ArticleNanomaterials (Basel, Switzerland)2018
Optimization of Iron Oxide Tracer Synthesis for Magnetic Particle Imaging.
Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Multicore-based ferrofluids in zero field: initial magnetic susceptibility and self-assembly mechanisms.Soft matter · 2023Article
- Recent Advances in Multimodal Molecular Imaging of Cancer Mediated by Hybrid Magnetic Nanoparticles.Polymers · 2021Review
- Imaging Constructs: The Rise of Iron Oxide Nanoparticles.Molecules (Basel, Switzerland) · 2021Review
- Microemulsion Synthesis of Superparamagnetic Nanoparticles for Bioapplications.International journal of molecular sciences · 2021Article
- The Applications of Magnetic Particle Imaging: From Cell to Body.Diagnostics (Basel, Switzerland) · 2020Review
- MPI Phantom Study with A High-Performing Multicore Tracer Made by Coprecipitation.Nanomaterials (Basel, Switzerland) · 2019Article
- Zero-Field and Field-Induced Interactions between Multicore Magnetic Nanoparticles.Nanomaterials (Basel, Switzerland) · 2019Article
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Authors and funding
6 authors.
Funding
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Abstract
The optimization of iron oxide nanoparticles as tracers for magnetic particle imaging (MPI) alongside the development of data acquisition equipment and image reconstruction techniques is crucial for the required improvements in image resolution and sensitivity of MPI scanners. We present a large-scale water-based synthesis of multicore superparamagnetic iron oxide nanoparticles stabilized with dextran (MC-SPIONs). We also demonstrate the preparation of single core superparamagnetic iron oxide nanoparticles in organic media, subsequently coated with a poly(ethylene glycol) gallic acid polymer and phase transferred to water (SC-SPIONs). Our aim was to obtain long-term stable particles in aqueous media with high MPI performance. We found that the amplitude of the third harmonic measured by magnetic particle spectroscopy (MPS) at 10 mT is 2.3- and 5.8-fold higher than Resovist for the MC-SPIONs and SC-SPIONs, respectively, revealing excellent MPI potential as compared to other reported MPI tracer particle preparations. We show that the reconstructed MPI images of phantoms using optimized multicore and specifically single-core particles are superior to that of commercially available Resovist, which we utilize as a reference standard, as predicted by MPS.
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