Evidence map›Paper›PMID 29561772›Full record

ArticleViruses2018

The Host Factor Early Growth Response Gene (EGR-1) Regulates Vaccinia virus Infectivity during Infection of Starved Mouse Cells.

Leonardo C de Oliveira, Bruno S A F Brasil, Bethany Unger, Giliane S Trindade, Jonatas S Abrahão, Erna G Kroon, Paula Traktman, Cláudio A Bonjardim

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Leonardo C de OliveiraGrupo de Transdução de Sinal, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Minas, Brazil. ldeolive2@gmail.com.
Bruno S A F BrasilGrupo de Transdução de Sinal, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Minas, Brazil. brunosafb@gmail.com.
Bethany UngerDepartment of Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. bugs@mcw.edu.
Giliane S TrindadeLaboratório de Vírus, Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil. gitrindade@yahoo.com.br.
Jonatas S AbrahãoLaboratório de Vírus, Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil. jonatas.abrahao@gmail.com.
Erna G KroonLaboratório de Vírus, Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Minas Gerais, Brazil. ernagkroon@gmail.com.ORCID 0000-0003-2721-3826
Paula TraktmanDepartments of Biochemistry & Molecular Biology and Microbiology & Immunology, Medical University of South Carolina, Charleston, SC 29425, USA. traktman@musc.edu.
Cláudio A BonjardimGrupo de Transdução de Sinal, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Minas, Brazil. cbonjardim29@gmail.com.
Universidade Federal de Minas Gerais · BRMedical College of Wisconsin · USMedical University of South Carolina · US

Funding

VACCINIA DNA REPLICATION: GENETICS AND MOLECULAR BIOLOGYR01AI021758 · NIAID · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI TRAKTMAN, PAULA · 1985 to 2016
$5.8M
Vaccinia Encoded Kinases and PhosphatasesR01AI063620 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI TRAKTMAN, PAULA · 2005 to 2009
$1.8M
NIAID NIH HHS R01 AI021758NIAID NIH HHS R01 AI063620
6 · The paper itself

Abstract

Evolution has equipped poxvirus genomes with the coding capacity for several virus-host interaction products which interfere with host cell gene expression and protein function, creating an adequate intracellular environment for a productive infection. We show here that

Indexed as

Gene Expression RegulationAnimalsCell LineDisease Models, AnimalDNA ReplicationDNA, ViralEarly Growth Response Protein 1FibroblastsGene DeletionHost-Pathogen InteractionsMAP Kinase Signaling SystemMiceMice, KnockoutPhosphorylationVacciniaVaccinia virusDNA, ViralEarly Growth Response Protein 1Egr1 protein, mouseearly growth response-1 (EGR-1)mitogen-activated protein kinase (MAPK)Vaccinia virusvirus–host cell interaction

Identifiers

PMID29561772
PMCPMC5923434
OpenAlexW2793561523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.