Evidence map›Paper›PMID 29561604›Full record

ArticleJournal of the American Chemical Society2018

Photochemical Barcodes.

Sicheng Tang, Yang Zhang, Pravat Dhakal, Laura Ravelo, Cheyenne L Anderson, Kevin M Collins, Françisco M Raymo

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Photoactivation of BODIPY Fluorescence with Green Light.The Journal of organic chemistry · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Photoactivatable BODIPYs for Live-Cell PALM.Molecules (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Article
  9. Identification of Toxicity Effects of CuEnvironmental science. Nano · 2020
    Article
  10. Article
  11. Solution and Solid-State Emission Toggling of a Photochromic Hydrazone.Journal of the American Chemical Society · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sicheng TangLaboratory for Molecular Photonics, Departments of Biology and Chemistry , University of Miami , 1301 Memorial Drive , Coral Gables , Florida 33146-0431 , United States.
Yang ZhangLaboratory for Molecular Photonics, Departments of Biology and Chemistry , University of Miami , 1301 Memorial Drive , Coral Gables , Florida 33146-0431 , United States.ORCID 0000-0003-1011-3001
Pravat DhakalLaboratory for Molecular Photonics, Departments of Biology and Chemistry , University of Miami , 1301 Memorial Drive , Coral Gables , Florida 33146-0431 , United States.
Laura RaveloLaboratory for Molecular Photonics, Departments of Biology and Chemistry , University of Miami , 1301 Memorial Drive , Coral Gables , Florida 33146-0431 , United States.
Cheyenne L AndersonLaboratory for Molecular Photonics, Departments of Biology and Chemistry , University of Miami , 1301 Memorial Drive , Coral Gables , Florida 33146-0431 , United States.
Kevin M CollinsLaboratory for Molecular Photonics, Departments of Biology and Chemistry , University of Miami , 1301 Memorial Drive , Coral Gables , Florida 33146-0431 , United States.ORCID 0000-0001-9930-0924
Françisco M RaymoLaboratory for Molecular Photonics, Departments of Biology and Chemistry , University of Miami , 1301 Memorial Drive , Coral Gables , Florida 33146-0431 , United States.ORCID 0000-0002-6163-6606
University of Miami · US

Funding

Neuromodulator signaling and activity in the C. elegans egg-laying circuit.R01NS086932 · NINDS · YALE UNIVERSITY · PI Kevin Michael Collins, MICHAEL R KOELLE · 2014 to 2026
$5.2M
NINDS NIH HHS R01 NS086932
6 · The paper itself

Abstract

A photochemical strategy to encode fluorescence signals in vivo with spatial control was designed around the unique properties of a photoactivatable borondipyrromethene (BODIPY). The photoinduced disconnection of two oxazines, flanking a single BODIPY, in two consecutive steps produces a mixture of three emissive molecules with resolved fluorescence inside polymer beads. The relative amounts and emission intensities of the three fluorophores can be regulated precisely in each bead by adjusting the dose of activating photons to mark individual particles with distinct codes of fluorescence signals. The visible wavelengths and mild illumination sufficient to induce these transformations permit the photochemical barcoding of beads also in living nematodes. Different regions of the same animal can be labeled with distinct barcodes to allow the monitoring of their dynamics for long times with no toxic effects. Thus, our photochemical strategy for the generation of fluorescence barcodes can produce multiple and distinguishable labels in the same biological sample to enable the spatiotemporal tracking of, otherwise indistinguishable, targets.

Indexed as

DNA Barcoding, TaxonomicLightBoron CompoundsOxyquinoline4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsOxyquinoline

Identifiers

PMID29561604
PMCPMC6056178
OpenAlexW4241551375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.