ArticleOptometry and vision science : official publication of the American Academy of Optometry2018
Effects of Thickness on Corneal Biomechanical Properties Using Optical Coherence Elastography.
Article in Optometry and vision science : official publication of the American Academy of Optometry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Sensitivity of the iFalconBMC veterinary research · 2026Article
- Air-Coupled Ultrasonic Optical Coherence Elastography Reveals Protocol-Dependent Corneal Stiffening in Epi-On and Epi-Off Riboflavin Crosslinking.Translational vision science & technology · 2026Article
- Evaluation of the iFalconBMC veterinary research · 2026Article
- Central Corneal Thickness and Glaucoma Risk: The Importance of Corneal Pachymetry in Screening Adults Over 50 and Glaucoma Suspects.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Influence of Dextran Solution and Corneal Collagen Crosslinking on Corneal Biomechanical Parameters Evaluated by Corvis ST In Vitro.Bioengineering (Basel, Switzerland) · 2024Article
- Dynamic evaluation of corneal cross-linking and osmotic diffusion effects using optical coherence elastography.Scientific reports · 2024Article
- Article
- Acute alcohol consumption modulates corneal biomechanical properties as revealed by optical coherence elastography.Journal of biomechanics · 2024Article
- Corneal hysteresis and intraocular pressure are altered in silicone-hydrogel soft contact lenses wearers.International ophthalmology · 2022Article
- Longitudinal assessment of the effect of alkali burns on corneal biomechanical properties using optical coherence elastography.Journal of biophotonics · 2022Article
- In vivo human corneal natural frequency quantification using dynamic optical coherence elastography: Repeatability and reproducibility.Journal of biomechanics · 2021Article
- Compressional Optical Coherence Elastography of the Cornea.Photonics · 2021Article
- Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration.Translational vision science & technology · 2020Article
- Simultaneously imaging and quantifyingAPL photonics · 2019Article
- Line-Field Optical Coherence Tomography as a tool for In vitro characterization of corneal biomechanics under physiological pressures.Scientific reports · 2019Article
- Theory and design of Schwarzschild scan objective for Optical Coherence Tomography.Optics express · 2019Article
- Noninvasive Assessment of Corneal Crosslinking With Phase-Decorrelation Optical Coherence Tomography.Investigative ophthalmology & visual science · 2019Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
significanceMeasured corneal biomechanical properties are driven by intraocular pressure, tissue thickness, and inherent material properties. We demonstrate tissue thickness as an important factor in the measurement of corneal biomechanics that can confound short-term effects due to UV riboflavin cross-linking (CXL) treatment. PURPOSE: We isolate the effects of tissue thickness on the measured corneal biomechanical properties using optical coherence elastography by experimentally altering the tissue hydration state and stiffness.
methodsDynamic optical coherence elastography was performed using phase-sensitive optical coherence tomography imaging to quantify the tissue deformation dynamics resulting from a spatially discrete, low-force air pulse (150-μm spot size; 0.8-millisecond duration; <10 Pa [<0.08 mmHg]). The time-dependent surface deformation is characterized by a viscoelastic tissue recovery response, quantified by an exponential decay constant-relaxation rate. Ex vivo rabbit globes (n = 10) with fixed intraocular pressure (15 mmHg) were topically instilled every 5 minutes with 0.9% saline for 60 minutes and 20% dextran for another 60 minutes. Measurements were made after every 20 minutes to determine the central corneal thickness (CCT) and the relaxation rates. Cross-linking treatment was performed on another 13 eyes, applying isotonic riboflavin (n = 6) and hypertonic riboflavin (n = 7) every 5 minutes for 30 minutes, followed by UV irradiation (365 nm, 3 mW/cm) for 30 minutes while instilling riboflavin. Central corneal thickness and relaxation rates were obtained before and after CXL treatment.
resultsCorneal thickness was positively correlated (R = 0.9) with relaxation rates. In the CXL-treated eyes, isotonic riboflavin did not affect CCT and showed a significant increase in relaxation rates (+10%; P = .01) from 2.29 ms to 2.53 ms. Hypertonic riboflavin showed a significant CCT decrease (-31%; P = .01) from 618 μm to 429 μm but showed little change in relaxation rates after CXL treatment.
conclusionsCorneal thickness and stiffness are correlated positively. A higher relaxation rate implied stiffer material properties after isotonic CXL treatment. Hypertonic CXL treatment results in a stiffness decrease that offsets the stiffness increase with CXL treatment.
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