ArticleMedicine2018
Effect of selective serotonin reuptake inhibitor treatment on the prognosis of patients with medication overuse headache.
Article in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medication overuse headache is a disabling headache disorder. Withdraw treatment plus preventive medication may lead to a better outcome. However, the effect of selective serotonin reuptake inhibitor on the treatment of medication overuse headache is still unknown.In this study, we followed up medication overuse headache patients diagnosed at the West China Hospital at an average follow-up duration of 1.5 years to analyze patients' outcomes and relapse. We used logistic regression to assess the relationship between patient medication and effect of withdrawal treatment. We used COX (cox regression model) regression analysis to assess the relationship between withdrawal treatments and relapse rate in patients.A total of 72 medication overuse headache patients were enrolled in this study, of which 14 (19.4%) failed to withdraw therapy, 58 got a good response to withdraw therapy. Among responders, there are 5 (8.6%) relapse patients. Selective serotonin reuptake inhibitor treatment can increase the effect of withdrawal therapy (odds ratio [OR] = 0.016, 95% confidence interval [CI]: 0.003, 0.091, P < .001) and it was an important predictor of patients' outcome (hazard ratio [HR] = 0.255, 95%CI: 0.09-0.724).Selective serotonin reuptake inhibitor can increase the therapeutic effect in medication overuse headache withdrawal therapy and can reduce the risk of relapse.
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Registered trials
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