Evidence map›Paper›PMID 29561299›Full record

ArticleThe Journal of nervous and mental disease2018

Motor Dysfunction as a Risk Factor for Conversion to Psychosis Independent of Medication Use in a Psychosis-Risk Cohort.

Michael D Masucci, Amanda Lister, Cheryl M Corcoran, Gary Brucato, Ragy R Girgis

Abstract read
In one paragraph

Article in The Journal of nervous and mental disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Schizophrenia polygenic risk score in psychosis proneness.European archives of psychiatry and clinical neuroscience · 2023
    Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael D MasucciThe Center of Prevention and Evaluation, New York State Psychiatric Institute, Columbia University Medical Center, New York, New York.
Amanda Lister
Cheryl M Corcoran
Gary Brucato
Ragy R Girgis
New York Psychoanalytic Society and Institute · US

Funding

Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VONSATTEL, JEAN PAUL GERARD · 1989 to 2019
$46.3M
Thought disorder and social cognition in clinical risk states for schizophreniaR01MH107558 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI CORCORAN, CHERYL MARY · 2016 to 2020
$3.3M
Longitudinal Imaging of Patients at Clinical Risk for Psychosis.R01MH093398 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SMALL, SCOTT A · 2011 to 2015
$2.5M
Schizophrenia risk to onset: Neurobiology and preventionK23MH066279 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CORCORAN, CHERYL MARY · 2004 to 2008
$884k
Olfaction in the Psychosis Prodrome: Behavioral and ERP MeasuresR21MH086125 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BRUDER, GERARD E, CORCORAN, CHERYL MARY · 2009 to 2010
$440k
Multimodal MR Imaging of the Glutamate System in SchizophreniaK23MH106746 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI GIRGIS, RAGY RAMSIS · 2015 to 2016
$370k
NIA NIH HHS P50 AG008702NIMH NIH HHS K23 MH066279NIMH NIH HHS K23 MH106746NIMH NIH HHS R01 MH093398NIMH NIH HHS R01 MH107558
6 · The paper itself

Abstract

The Structured Interview for Psychosis-Risk Syndromes (SIPS) contains criteria for the Attenuated Positive Symptom Syndrome (APSS), a period of subthreshold positive symptoms that predates full-blown psychosis. Motor abnormalities are often associated with these symptoms but have not been adequately studied. We assessed a diverse sample of 192 APSS participants (27.1% female; 47.9% white; mean age = 20.03 years) for motor dysfunction (SIPS G.3. score) at baseline and conversion to psychosis every 3 months for up to 2 years. Fifty-nine (30.7%) participants converted to psychosis. Baseline G.3. score was significantly higher among converters than nonconverters (mean difference = 0.66; t[95.929] = 2.579, p < 0.05). No significant differences in baseline G.3. were found between demographic groups or those with differential medication use. These results point to the use of G.3. as a potential predictor of psychosis among APSS individuals and potentially implicate the shared biological underpinnings of motor dysfunction in the APSS and full-blown psychotic illnesses.

Indexed as

Antipsychotic AgentsFemaleHumansInterview, PsychologicalMaleMotor DisordersProdromal SymptomsPsychotic DisordersRisk FactorsYoung AdultAntipsychotic Agents

Identifiers

PMID29561299
PMCPMC5899031
OpenAlexW2789470834

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.