Trial reportEuropean journal of anaesthesiology2018
Protective ventilation during anaesthesia reduces major postoperative complications after lung cancer surgery: A double-blind randomised controlled trial.
Trial report in European journal of anaesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00805077 (Pulmonary Surgery and Protective Mechanical Ventilation), which is not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pulmonary Surgery and Protective Mechanical Ventilation
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Effect of intraoperative ventilation strategy on postoperative pulmonary complications in thoracic surgery under general anesthesia: a meta-analysis.Journal of cardiothoracic surgery · 2026Pooled it
- Driving pressure-guided ventilation during one-lung ventilation for thoracic surgery: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Effect of Intraoperative Ventilation Strategies on Postoperative Pulmonary Complications: A Meta-Analysis.Frontiers in surgery · 2021Pooled it
- Perioperative Normobaric Hyperoxia Combined With Pulmonary Rehabilitation Intervention for Enhanced Short-Term Recovery in Lung Cancer Surgery.Thoracic cancer · 2026Trial
- Effect of dynamic lung compliance-guided positive end-expiratory pressure on postoperative pulmonary complications following thoracoscopic lobectomy: a randomized controlled trial.BMC anesthesiology · 2025Trial
- An optimal protective ventilation strategy in lung resection surgery: a prospective, single-center, three-arm randomized controlled trial.Updates in surgery · 2025Trial
- Effects of intraoperative lung-protective ventilation on clinical outcomes in patients with traumatic brain injury: a randomized controlled trial.BMC anesthesiology · 2021Trial
- Effect of intraoperative lung-protective mechanical ventilation on pulmonary oxygenation function and postoperative pulmonary complications after laparoscopic radical gastrectomy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Trial
- Stellate ganglion block for attenuating postoperative sore throat after double-lumen tube intubation in thoracic surgery: a randomized clinical study.Perioperative medicine (London, England) · 2026Article
- Postoperative pulmonary complications and response to recruitment maneuvers during hypoxemia in one lung ventilation.BMC anesthesiology · 2026Observational
- Variation in and deviation from protective ventilation during lung surgery.JTCVS techniques · 2026Article
- Postoperative outcomes following anatomical lung resections in relation to intraoperative ventilation practices: a registry-based multicenter study.Frontiers in surgery · 2026Article
- Individualized Perioperative PEEP in Older Surgical Patients: A Three-Dimensional Titration Framework.Clinical interventions in aging · 2026Review
- Intraoperative Ventilatory Strategies in Patients Undergoing Video-Assisted Thoracic Surgery: A Narrative Review.Advances in therapy · 2025Review
- Exploring Benefits of Non-Intubated Surgery for Lung Biopsy in Interstitial Lung Disease.Respirology (Carlton, Vic.) · 2025Article
- Comparison of low vs high tidal volumes in one-lung ventilation during thoracic surgery: a propensity-weighted cohort study.Scientific reports · 2025Observational
- Remimazolam mitigates oxidative stress response in patients undergoing one-lung ventilation.Frontiers in surgery · 2025Article
- Impact of intraoperative ventilation parameters on postoperative outcomes in thoracic surgery: a multicenter registry-based analysis.Frontiers in surgery · 2025Article
- Bronchial Blockers versus Double-Lumen Endotracheal Tubes: Impact on Postoperative Pneumonia in Lung Cancer Patients Undergoing Video-Assisted Thoracoscopic Surgery - A Propensity Score-Matched Study.Risk management and healthcare policy · 2025Article
- Virtual reality-assisted pulmonary rehabilitation enhances early lung function recovery after thoracoscopic surgery in lung cancer patients: a non-concurrent controlled study.Frontiers in medicine · 2025Article
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThoracic surgery for lung resection is associated with a high incidence of postoperative pulmonary complications. Controlled ventilation with a large tidal volume has been documented to be a risk factor for postoperative respiratory complications after major abdominal surgery, whereas the use of low tidal volumes and positive end-expiratory pressure (PEEP) has a protective effect.
objectiveTo evaluate the effects of ventilation with low tidal volume and PEEP on major complications after thoracic surgery.
designA double-blind, randomised controlled study.
settingA multicentre trial from December 2008 to October 2011. PATIENTS: A total of 346 patients undergoing lobectomy or pneumonectomy for lung cancer.
main outcome measuresThe primary outcome was the occurrence of major postoperative complications (pneumonia, acute lung injury, acute respiratory distress syndrome, pulmonary embolism, shock, myocardial infarction or death) within 30 days after surgery.
interventionsPatients were randomly assigned to receive either lung-protective ventilation (LPV group) [tidal volume 5 ml kg ideal body weight + PEEP between 5 and 8 cmH2O] or nonprotective ventilation (control group) (tidal volume 10 ml kg ideal body weight without PEEP) during anaesthesia.
resultsThe trial was stopped prematurely because of an insufficient inclusion rate. Major postoperative complications occurred in 23/172 patients in the LPV group (13.4%) vs. 38/171 (22.2%) in the control group (odds ratio 0.54, 95% confidence interval, 0.31 to 0.95, P = 0.03). The incidence of other complications (supraventricular cardiac arrhythmia, bronchial obstruction, pulmonary atelectasis, hypercapnia, bronchial fistula and persistent air leak) was also lower in the LPV group (37.2 vs. 49.4%, odds ratio 0.60, 95% confidence interval, 0.39 to 0.92, P = 0.02).The duration of hospital stay was shorter in the LPV group, 11 [interquartile range, 9 to 15] days vs. 12 [9 to 16] days, P = 0.048.
conclusionCompared with high tidal volume and no PEEP, LPV combining low tidal volume and PEEP during anaesthesia for lung cancer surgery seems to improve postoperative outcomes. TRIALS REGISTRATION: ClinicalTrials.gov number: NCT00805077.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.