ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Abnormal Functional Connectivity Between Default and Salience Networks in Pediatric Bipolar Disorder.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 37 citations in OpenAlex.
- fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial.BMC medicine · 2026Trial
- Early Family Intervention for Youth at Risk for Bipolar Disorder: Psychosocial and Neural Mediators of Outcome.Current neuropharmacology · 2023Trial
- The Role of Temperament Traits in Bipolar Disorder: Neuroimaging Study.Depression and anxiety · 2025Article
- Effects of insecure attachment on fMRI resting state functional connectivity in poly drug use disorder.PloS one · 2025Observational
- Lactate flux dysfunction in patients with bipolar disorder: preliminary insights from ultra-high field 7T MRSI during task and rest.Frontiers in neuroscience · 2025Article
- Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study.BMC psychiatry · 2024Article
- Altered brain texture features in end-stage renal disease patients: a voxel-based 3D brain texture analysis study.Frontiers in neuroscience · 2024Article
- Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder.Molecular psychiatry · 2023Article
- Does the Brain Matter? Cortical Alterations in Pediatric Bipolar Disorder: A Critical Review of Structural and Functional Magnetic Resonance Studies.Current neuropharmacology · 2023Review
- Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies.Translational psychiatry · 2022Review
- Neural Connectivity Underlying Reward and Emotion-Related Processing: Evidence From a Large-Scale Network Analysis.Frontiers in systems neuroscience · 2022Article
- Assessing atypical brain functional connectivity development: An approach based on generative adversarial networks.Frontiers in neuroscience · 2022Article
- Default-mode and fronto-parietal network connectivity during rest distinguishes asymptomatic patients with bipolar disorder and major depressive disorder.Translational psychiatry · 2021Article
- Cannabis use and resting state functional connectivity in adolescent bipolar disorder.Journal of psychiatry & neuroscience : JPN · 2021Article
- Changes in Intrinsic Brain Connectivity in Family-Focused Therapy Versus Standard Psychoeducation Among Youths at High Risk for Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder.Neural plasticity · 2020Article
- Neuroimaging in Psychiatry and Neurodevelopment: why the emperor has no clothes.The British journal of radiology · 2019Review
- Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory.Human brain mapping · 2018Article
- Individual differences in aesthetic engagement are reflected in resting-state fMRI connectivity: Implications for stress resilience.NeuroImage · 2018Article
- Bilateral Transcranial Magnetic Stimulation on DLPFC Changes Resting State Networks and Cognitive Function in Patients With Bipolar Depression.Frontiers in human neuroscience · 2018Article
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7 authors at 3 institutions in 1 country.
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Abstract
backgroundPediatric bipolar disorder (PBD) (occurring prior to 18 years of age) is a developmental brain disorder that is among the most severe and disabling psychiatric conditions affecting youth. Despite increasing evidence that brain connectivity is atypical in adults with bipolar disorder, it is not clear how brain connectivity may be altered in youths with PBD.
methodsThis cross-sectional resting-state functional magnetic resonance imaging study included 80 participants recruited over 4 years: 32 youths with PBD, currently euthymic (13 males; 15.1 years old), and 48 healthy control (HC) subjects (27 males; 14.5 years old). Functional connectivity between eight major intrinsic connectivity networks, along with connectivity measurements between 333 brain regions, was compared between PBD and HC subjects. Additionally, connectivity differences were evaluated between PBD and HC samples in negatively correlated connections, as defined by 839 subjects of the Human Connectome Project dataset.
resultsWe found increased inter- but not intranetwork functional connectivity in PBD between the default mode and salience networks (p = .0017). Throughout the brain, atypical connections showed failure to develop anticorrelation with age during adolescence in PBD but not HC samples among connections that exhibit negative correlation in adulthood.
conclusionsYouths with PBD demonstrate reduced anticorrelation between default mode and salience networks. Further evaluation of the interaction between these networks is needed in development and with other mood states such as depression and mania to clarify if this atypical connectivity is a PBD trait biomarker.
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