ReviewThe journal of physiological sciences : JPS2018
Role of GABA in the regulation of the central circadian clock of the suprachiasmatic nucleus.
Review in The journal of physiological sciences : JPS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Systematic review of drugs that modify the circadian system's phase-shifting responses to light exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Article
- Nos1 neurons in the paraventricular hypothalamic area modulate lipid metabolism via the sympathetic nervous system in male mice.Nature communications · 2026Article
- Research progress and future directions in circadian rhythms for uterine‑related diseases (Review).Molecular medicine reports · 2026Review
- Alcohol and Opioids Modulate Excitatory Inputs to the SCN.bioRxiv : the preprint server for biology · 2026Article
- A GABAergic network from AVP- to VIP-neurons in the suprachiasmatic nucleus sets the timing of circadian behavior rhythms.PLoS biology · 2026Article
- Integrating Astrocytes in the Sleep-Wake Cycle: The Time Is Now.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Chronotype in alpha-tACS: Preliminary evidence hints at sleep quality modulation of aftereffects in evening types in the morning.Neurobiology of sleep and circadian rhythms · 2025Article
- Review
- Citronellal Exerts Sedative-Like Effects and Augments Diazepam's Action in Swiss Mice, Possibly Through the GABAergic Pathway.Brain and behavior · 2025Article
- Article
- Insomnia treatment based on the regulation of the GABAergic system: traditional Chinese medicine perspectives and therapeutic approaches.Frontiers in neuroscience · 2025Review
- Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNCommunications biology · 2024Article
- GABAergic signalling in the suprachiasmatic nucleus is required for coherent circadian rhythmicity.The European journal of neuroscience · 2024Article
- Efferent pathways from the suprachiasmatic nucleus to the horizontal limbs of diagonal band promote NREM sleep during the dark phase in mice.BMC neuroscience · 2024Article
- System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning.Cell research · 2024Article
- Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development.iScience · 2024Article
- The behavioral and physiological correlates of affective mood switching in premenstrual dysphoric disorder.Frontiers in psychiatry · 2024Review
- Bidirectional mechanism of comorbidity of depression and insomnia based on synaptic plasticity.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Transcriptomic Analysis of Light-Induced Genes inBiology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
In mammals, circadian rhythms, such as sleep/wake cycles, are regulated by the central circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN consists of thousands of individual neurons, which exhibit circadian rhythms. They synchronize with each other and produce robust and stable oscillations. Although several neurotransmitters are expressed in the SCN, almost all SCN neurons are γ-amino butyric acid (GABA)-ergic. Several studies have attempted to understand the roles of GABA in the SCN; however, precise mechanisms of the action of GABA in the SCN are still unclear. GABA exhibits excitatory and/or inhibitory characteristics depending on the circadian phase or region in the SCN. It can both synchronize and destabilize cellular circadian rhythms in individual SCN cells. Differing environmental light conditions, such as a long photoperiod, result in the decoupling of circadian oscillators of the dorsal and ventral SCN. This is due to high intracellular chloride concentrations in the dorsal SCN. Because mice with functional GABA deficiency, such as vesicular GABA transporter- and glutamate decarboxylase-deficient mice, are neonatal lethal, research has been limited to pharmacological approaches. Furthermore, different recording methods have been used to understand the roles of GABA in the SCN. The excitability of GABAergic neurons also changes during the postnatal period. Although there are technical difficulties in understanding the functions of GABA in the SCN, technical developments may help uncover new roles of GABA in circadian physiology and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.