ArticleInternational orthopaedics2018
Understanding the factors that influence patient participation in Orthopaedic Clinical Trials.
Article in International orthopaedics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05483673 (A Comprehensive Study for Analyzing Orthopedic Patient Experience Patterns in Medical Trials), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comprehensive Study for Analyzing Orthopedic Patient Experience Patterns in Medical Trials
Who cites it
1 citing paper in PubMed.
- Anything is better than nothing': exploring attitudes towards novel therapies in leukodystrophy clinical trials.Orphanet journal of rare diseases · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the knowledge, attitudes and perceptions of orthopaedic patients towards participating in clinical trials (CTs).
methodsA cross-sectional study was conducted on 200 adult orthopaedic patients at a Tertiary Orthopaedic Centre. Data was collected using a self-completed questionnaire. Statistical analysis was used to compare responses between those that would and would not participate using the chi-squared and the Mann-Whitney U testing.
resultsEighty-four percent of the patients (n = 168) stated that they would be happy to participate in clinical trials research. However, 94% (n = 188) had never had a clinical trial discussed with them previously while only 4.5% (n = 9) had participated in a clinical trial to their knowledge. The main reason for participating in clinical trials was 'I believe results could help other patients in the future' with 58% selecting this option (n = 116). Travel distance was cited as the most important barrier to taking part (n = 83, 55%). Travel distance was also seen as significantly more important in patients who were willing to participate than patient who were not (n = 10, 33%) p = 0.04. There was no significant difference between groups in responses to the statement 'I have concerns over the use and storage of blood and tissue', (Mean score = 3.46, Mean score = 3.13, p = 0.89).
conclusionThe prevailing sentiment is that patients are overwhelmingly positive towards participation in clinical trials. This study highlights that there appears to be an opportunity to improve the recruitment of clinical trial in orthopaedics thus improving evidence-based practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.