ArticleArthroplasty today2018
Tranexamic acid increases early perioperative functional outcomes after total knee arthroplasty.
Article in Arthroplasty today, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05099276 (Extended Postoperative Tranexamic Acid Use in Primary Total Knee Arthroplasty), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Extended Postoperative Tranexamic Acid Use in Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Trial
Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels.The Journal of bone and joint surgery. American volume · 2019Trial
- High-dose (3 g) topical tranexamic acid has higher potency in reducing blood loss after total knee arthroplasty compared with low dose (500 mg): a double-blind randomized controlled trial.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Trial
- Administration of Perioperative Tranexamic Acid and Range of Motion After Total Shoulder Arthroplasty.Journal of shoulder and elbow arthroplasty · 2025Article
- Impact of Topical Tranexamic Acid on Bleeding Control in Rhinoplasty.World journal of plastic surgery · 2024Article
- The effect of topical tranexamic acid on functional outcomes and quality of life in patients undergoing unicompartmental knee arthroplasty.Archives of orthopaedic and trauma surgery · 2023Article
- Using tranexamic acid for an additional 24 hours postoperatively in hip and knee arthroplasty saves money: a cost analysis from the TRAC-24 randomized control trial.Bone & joint open · 2022Article
- Effect of patellar resurfacing surgery on bleeding in total knee arthroplasty.Revista da Associacao Medica Brasileira (1992) · 2022Article
- Effectiveness of using tranexamic acid in total hip and total knee arthroplasty: Single tertiary center experience.Saudi medical journal · 2021Article
- The Efficacy of Intravenous Versus Topical Use of Tranexamic Acid in Reducing Blood Loss after Primary Total Knee Arthroplasty: A Randomized Clinical Trial.The archives of bone and joint surgery · 2020Article
- Is continuous locking suture with braided suture sufficient for arthrotomy repair in the conventional TKR? A randomized controlled trial study.Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to investigate the influence of tranexamic acid (TXA) on functional outcomes in the immediate postoperative period after total knee arthroplasty (TKA). We hypothesized that the known benefits of TXA would confer measurable clinical improvements in physical therapy (PT) performance, decrease pain, and decrease hospital length of stay (LOS).
methodsWe retrospectively analyzed 560 TKA patients, including 280 consecutive patients whose surgery was performed before the initiation of a standardized TXA protocol and the first 280 patients who received TXA after protocol initiation. Outcome measurements included postoperative changes in hemoglobin and hematocrit, LOS, pain scores, destination of discharge, and steps ambulated with PT over 5 sessions.
resultsTXA administration resulted in less overall drops in hemoglobin (
conclusionsIt is well known that TXA reduces postoperative anemia, but this study also demonstrates that it confers early perioperative functional benefits for TKA patients. Potential mechanisms for this benefit include reduced rates of postoperative anemia and reduced rates of hemarthroses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.