ArticleChild neurology open2018
Use of Cyclophosphamide in a Child With Fulminant Acute Disseminated Encephalomyelitis.
Article in Child neurology open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Acute hemorrhagic leukoencephalitis in an adult: prominent response with cyclophosphamide.Acta neurologica Belgica · 2023Article
- An Adult Case of Adenovirus-Associated Acute Disseminated Encephalomyelitis.Case reports in infectious diseases · 2023Article
- Assessment and Management of Acute Disseminated Encephalomyelitis (ADEM) in the Pediatric Patient.Paediatric drugs · 2021Review
- Update on Acute Disseminated Encephalomyelitis in Children and Adolescents.Children (Basel, Switzerland) · 2021Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute disseminated encephalomyelitis is an immune-mediated inflammatory demyelinating disorder of the central nervous system. The first-line treatment is usually high-dose intravenous methylprednisolone. Intravenous immunoglobulin and plasmapheresis have also shown to be beneficial. Immunosuppressive agents like cyclophosphamide have been used in adults with fulminant acute disseminated encephalomyelitis. We report a case of a 3-year-old boy with fulminant acute disseminated encephalomyelitis. Minimal improvement was seen with high-dose intravenous methylprednisolone, intravenous immunoglobulin, and plasmapheresis. Based on the reports of cyclophosphamide being used successfully to treat adult patients with fulminant acute disseminated encephalomyelitis, we used it in our patient who then showed dramatic and quick improvement. We suggest that if conventional treatment fails, cyclophosphamide could be tried in pediatric patients with fulminant acute disseminated encephalomyelitis.
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Registered trials
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