Evidence map›Paper›PMID 29560179›Full record

ArticleChemical science2015

Multiplexed DNA detection based on positional encoding/decoding with self-assembled DNA nanostructures.

Sha Sun, Huaxin Yao, Feifei Zhang, Jin Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sha SunDepartment of Polymer Science and Engineering , School of Chemistry and Chemical Engineering , State Key Laboratory of Coordination Chemistry , Nanjing National Laboratory of Microstructures , Nanjing University , Nanjing 210093 , China . Email: jinz@nju.edu.cn.
Huaxin YaoDepartment of Polymer Science and Engineering , School of Chemistry and Chemical Engineering , State Key Laboratory of Coordination Chemistry , Nanjing National Laboratory of Microstructures , Nanjing University , Nanjing 210093 , China . Email: jinz@nju.edu.cn.
Feifei ZhangDepartment of Polymer Science and Engineering , School of Chemistry and Chemical Engineering , State Key Laboratory of Coordination Chemistry , Nanjing National Laboratory of Microstructures , Nanjing University , Nanjing 210093 , China . Email: jinz@nju.edu.cn.
Jin ZhuDepartment of Polymer Science and Engineering , School of Chemistry and Chemical Engineering , State Key Laboratory of Coordination Chemistry , Nanjing National Laboratory of Microstructures , Nanjing University , Nanjing 210093 , China . Email: jinz@nju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current multiplexed analysis methods suffer from either slow reaction kinetics (planar arrays) or complicated encoding/decoding procedures (suspension arrays). We report herein a multiplexed DNA detection strategy that addresses these issues, based on positional encoding/decoding with self-assembled DNA nanostructures. The strategy enables the acquisition of high-resolution, consistent, and quantitative assay results in a single round of a transmission electron microscopy imaging operation. Applications in polymerase chain reaction-free settings and assays of other structurally distinct targets can be anticipated through the implementation of the strategy with miniaturized femtoliter/attoliter dispensing technology and readily accessible DNA conjugate structures.

Identifiers

PMID29560179
PMCPMC5811145

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.