Evidence map›Paper›PMID 29560124›Full record

ArticleOncotarget2018

CD30-targeted oncolytic viruses as novel therapeutic approach against classical Hodgkin lymphoma.

Julia D S Hanauer, Benjamin Rengstl, Dina Kleinlützum, Johanna Reul, Anett Pfeiffer, Thorsten Friedel, Irene C Schneider, Sebastian Newrzela, Martin-Leo Hansmann, Christian J Buchholz and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Julia D S HanauerMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Benjamin RengstlDr. Senckenberg Institute of Pathology, Goethe-University Frankfurt, Frankfurt am Main, Germany.
Dina KleinlützumMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Johanna ReulMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Anett PfeifferMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Thorsten FriedelMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Irene C SchneiderMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Sebastian NewrzelaDr. Senckenberg Institute of Pathology, Goethe-University Frankfurt, Frankfurt am Main, Germany.
Martin-Leo HansmannDr. Senckenberg Institute of Pathology, Goethe-University Frankfurt, Frankfurt am Main, Germany.
Christian J BuchholzMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Alexander MuikMolecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.
Paul Ehrlich Institut · DEBioNTech (Germany) · DEGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Classical Hodgkin lymphoma (cHL) is a hematopoietic malignancy with a characteristic cellular composition. The tumor mass is made up of infiltrated lymphocytes and other cells of hematologic origin but only very few neoplastic cells that are mainly identified by the diagnostic marker CD30. While most patients with early stage cHL can be cured by standard therapy, treatment options for relapsed or refractory cHL are still not sufficient, although immunotherapy-based approaches for the treatment of cHL patients have gained ground in the last decade. Here, we suggest a novel therapeutic concept based on oncolytic viruses selectively destroying the CD30

Indexed as

CD30classical Hodgkin lymphomaretargetingvirotherapyVSV

Identifiers

PMID29560124
PMCPMC5849188
OpenAlexW2784318462

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.