Evidence map›Paper›PMID 29560091›Full record

ArticleOncotarget2018

Epigenetic modifications in hyperhomocysteinemia: potential role in diabetic retinopathy and age-related macular degeneration.

Khaled Elmasry, Riyaz Mohamed, Isha Sharma, Nehal M Elsherbiny, Yutao Liu, Mohamed Al-Shabrawey, Amany Tawfik

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

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  14. Editorial: Insights in renal endocrinology: 2021.Frontiers in endocrinology · 2022
    Article
  15. Implication ofInternational journal of molecular sciences · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Khaled ElmasryDepartment of Oral Biology and Anatomy, Dental College of Georgia, Augusta University, Augusta, GA, USA.
Riyaz MohamedDepartment of Oral Biology and Anatomy, Dental College of Georgia, Augusta University, Augusta, GA, USA.
Isha SharmaDepartment of Oral Biology and Anatomy, Dental College of Georgia, Augusta University, Augusta, GA, USA.
Nehal M ElsherbinyDepartment of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Yutao LiuDepartment of Cellular Biology and Anatomy, Medical College of Georgia (MCG), Augusta University, Augusta, GA, USA.
Mohamed Al-ShabraweyDepartment of Oral Biology and Anatomy, Dental College of Georgia, Augusta University, Augusta, GA, USA.
Amany TawfikDepartment of Oral Biology and Anatomy, Dental College of Georgia, Augusta University, Augusta, GA, USA.
Discovery Institute · USAugusta University · USMansoura University · EG

Funding

Role of lipoxygenase pathway in early microvascular dysfunction during diabetic rR01EY023315 · NEI · AUGUSTA UNIVERSITY · PI AL-SHABRAWEY, MOHAMED AL-SAYED · 2013 to 2017
$1.8M
NEI NIH HHS R01 EY023315
6 · The paper itself

Abstract

To study Hyperhomocysteinemia (HHcy)-induced epigenetic modifications as potential mechanisms of blood retinal barrier (BRB) dysfunction, retinas isolated from three- week-old mice with elevated level of Homocysteine (Hcy) due to lack of the enzyme cystathionine β-synthase (

Indexed as

age-related macular degenerationblood retinal barrierdiabetic retinopathyepigenetic modificationsGerotargethyperhomocysteinemia

Identifiers

PMID29560091
PMCPMC5849155
OpenAlexW2794122823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.