ArticleFrontiers in neuroscience2018
A Compact Closed-Loop Optogenetics System Based on Artifact-Free Transparent Graphene Electrodes.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Battery-free, fully wireless neurostimulation via radiative RF power transfer in freely behaving mice.Microsystems & nanoengineering · 2026Article
- Far-field wireless power transmission module with MEMS-based laser steering for optogenetic applications.iScience · 2025Article
- Transparent MXene Microelectrode Arrays for Multimodal Mapping of Neural Dynamics.Advanced healthcare materials · 2025Article
- Innovating beyond electrophysiology through multimodal neural interfaces.Nature reviews electrical engineering · 2025Article
- From microelectrode arrays to all-optical and multimodal neural interfaces: emerging platforms for spatiotemporal interrogation ofFrontiers in synaptic neuroscience · 2025Review
- Neurophysiological measurements of planarian brain activity: a unique model for neuroscience research.Biology open · 2024Article
- Wireless closed-loop deep brain stimulation using microelectrode array probes.Journal of Zhejiang University. Science. B · 2024Review
- Flexible electronic-photonic 3D integration from ultrathin polymer chiplets.Npj flexible electronics · 2024Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Wireless and battery-free technologies for neuroengineering.Nature biomedical engineering · 2023Review
- Functional Two-Dimensional Materials for Bioelectronic Neural Interfacing.Journal of functional biomaterials · 2023Review
- Double-Sided Sapphire Optrodes with Conductive Shielding Layers to Reduce Optogenetic Stimulation Artifacts.Micromachines · 2022Article
- E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies.Cell reports · 2022Article
- Emerging Optoelectronic Devices Based on Microscale LEDs and Their Use as Implantable Biomedical Applications.Micromachines · 2022Review
- Multilayer CVD graphene electrodes using a transfer-free process for the next generation of optically transparent and MRI-compatible neural interfaces.Microsystems & nanoengineering · 2022Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Decoding of cortex-wide brain activity from local recordings of neural potentials.Journal of neural engineering · 2021Article
- Influence of the Surface Material and Illumination upon the Performance of a Microelectrode/Electrolyte Interface in Optogenetics.Micromachines · 2021Article
- Multi-modal artificial dura for simultaneous large-scale optical access and large-scale electrophysiology in non-human primate cortex.Journal of neural engineering · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrophysiology is a decades-old technique widely used for monitoring activity of individual neurons and local field potentials. Optogenetics has revolutionized neuroscience studies by offering selective and fast control of targeted neurons and neuron populations. The combination of these two techniques is crucial for causal investigation of neural circuits and understanding their functional connectivity. However, electrical artifacts generated by light stimulation interfere with neural recordings and hinder the development of compact closed-loop systems for precise control of neural activity. Here, we demonstrate that transparent graphene micro-electrodes fabricated on a clear polyethylene terephthalate film eliminate the light-induced artifact problem and allow development of a compact battery-powered closed-loop optogenetics system. We extensively investigate light-induced artifacts for graphene electrodes in comparison to metal control electrodes. We then design optical stimulation module using micro-LED chips coupled to optical fibers to deliver light to intended depth for optogenetic stimulation. For artifact-free integration of graphene micro-electrode recordings with optogenetic stimulation, we design and develop a compact closed-loop system and validate it for different frequencies of interest for neural recordings. This compact closed-loop optogenetics system can be used for various applications involving optogenetic stimulation and electrophysiological recordings.
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