Evidence map›Paper›PMID 29559853›Full record

ArticleCancer cell international2018

LncRNA XIST/miR-200c regulates the stemness properties and tumourigenicity of human bladder cancer stem cell-like cells.

Ran Xu, Xuan Zhu, Fangzhi Chen, Changkun Huang, Kai Ai, Hongtao Wu, Lei Zhang, Xiaokun Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  12. Review
  13. Long noncoding RNAGenes & diseases · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Long Non-coding RNAs, LncSub-cellular biochemistry · 2022
    Article
  18. Long non-coding RNA XIST: a novel oncogene in multiple cancers.Molecular medicine (Cambridge, Mass.) · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ran XuDepartment of Urology, The Second Xiangya Hospital, Central South University, Middle Renmin Road No. 139, Changsha, 410011 Hunan China.
Xuan ZhuDepartment of Urology, The Second Xiangya Hospital, Central South University, Middle Renmin Road No. 139, Changsha, 410011 Hunan China.
Fangzhi ChenDepartment of Urology, The Second Xiangya Hospital, Central South University, Middle Renmin Road No. 139, Changsha, 410011 Hunan China.
Changkun HuangDepartment of Urology, The Second Xiangya Hospital, Central South University, Middle Renmin Road No. 139, Changsha, 410011 Hunan China.
Kai AiDepartment of Urology, The Second Xiangya Hospital, Central South University, Middle Renmin Road No. 139, Changsha, 410011 Hunan China.
Hongtao WuDepartment of Urology, The Second Xiangya Hospital, Central South University, Middle Renmin Road No. 139, Changsha, 410011 Hunan China.
Lei ZhangDepartment of Urology, The Second Xiangya Hospital, Central South University, Middle Renmin Road No. 139, Changsha, 410011 Hunan China.
Xiaokun ZhaoDepartment of Urology, The Second Xiangya Hospital, Central South University, Middle Renmin Road No. 139, Changsha, 410011 Hunan China.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe abnormal expression of non-coding RNAs (ncRNAs), such as microRNAs and long ncRNAs, often contribute to the development of cancers. miR-200c functions as a tumour suppressor that impacts the growth of bladder cancer cells and the epithelial-to-mesenchymal transition (EMT). LncRNA X inactive specific transcript (XIST) is highly expressed in tumour tissues, promotes cancer progression and might act as an miRNA molecular sponge. This study aimed to examine the relationship between lncRNA XIST and miR-200c and to assess their functions in the regulation of the stemness properties and tumourigenicity of human bladder cancer stem cell (BCSC)-like cells.

methodsBiological effects including cell clone formation, sphere formation, self-renewal properties and mouse tumourigenesis were examined in BCSC-like cells with miR-200c overexpression or XIST knockdown. Real-time PCR and western blotting were used to detect the expression changing of related factors in BCSC-like cells gene models. Dual luciferase reporter assay was used to examine the changes of XIST and miR-200c expression levels.

resultsThe results indicated that miR-200c overexpression and XIST knockdown could inhibit cell clone formation, self-renewal ability and EMT in BCSC-like cells. miR-200c knockdown could restore the tumour growth inhibition caused by XIST knockdown.

conclusionLncRNA XIST may act as an inhibitor of miR-200c to regulate the stemness properties and tumourigenicity of bladder cancer cells, and our findings might reveal a potential strategy of targeting XIST for bladder cancer therapy.

Indexed as

Bladder cancerEMTLncRNAMiR-200cStem cell-like cellsXIST

Identifiers

PMID29559853
PMCPMC5859407
OpenAlexW2804198555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.