Evidence map›Paper›PMID 29559838›Full record

ReviewInternational journal of medical sciences2018

Decellularized Hydrogels in Bone Tissue Engineering: A Topical Review.

Andrea Pacifici, Luigi Laino, Marco Gargari, Federico Guzzo, Andrea Velandia Luz, Antonella Polimeni, Luciano Pacifici

Open access · goldAbstract readReview
In one paragraph

Review in International journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Review
  3. Therapeutic application of hydrogels for bone-related diseases.Frontiers in bioengineering and biotechnology · 2022
    Review
  4. Hydrogels and Their Role in Bone Tissue Engineering: An Overview.Journal of pharmacy & bioallied sciences · 2021
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. 3D Printing-Encompassing the Facets of Dentistry.Frontiers in bioengineering and biotechnology · 2018
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Andrea PacificiDepartment of Oral and Maxillofacial Sciences La Sapienza University of Rome, Italy.
Luigi LainoMultidisciplinary department of surgical and dental specialties. University of Campania Luigi Vanvitelli.
Marco GargariDepartment of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.
Federico GuzzoDepartment of Dentistry "Fra G.B. Orsenigo", Ospedale San Pietro FBF, Rome, Italy.
Andrea Velandia LuzAgEstimation Project, Institute of Legal Medicine, University of Macerata, Macerata, Italy.
Antonella PolimeniDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Italy.
Luciano PacificiDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Italy.
Sapienza University of Rome · ITOspedale San Pietro Fatebenefratelli · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Macerata · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nowadays, autograft and allograft techniques represent the main solution to improve bone repair. Unfortunately, autograft technique is expensive, invasive and subject to infections and hematoma, frequently affecting both donor sites and surgical sites. A recent advance in tissue engineering is the fabrication of cell-laden hydrogels with custom-made geometry, depending on the clinical case. The use of ECM (Extra-Cellular Matrix)-derived Hydrogels from bone tissue is the new opportunity to obtain good results in bone regeneration. Several micro-engineering techniques and approaches are available to fabricate different cell gradients and zonal structures in hydrogels design, in combination with the advancement in biomaterials selection. In this review, we analyse the stereolithografy, the Bio-patterning, the 3D bioprinting and 3D assembly, the Laser-Induced Forward Transfer Bioprinting (LIFT), the Micro-extrusion bioprinting, the promising Electrospinning technology, the Microfluidics and the Micromolding. Several mechanical properties are taken into account for bone regeneration scaffolds. However, each typology of scaffold presents some advantages and some concerns. The research on biomaterials is the most promising for bone tissue engineering: the new biomimetic materials will allow us to obtain optimal results in the next clinical application of basic research.

Indexed as

Tissue EngineeringTissue ScaffoldsBone RegenerationExtracellular MatrixHumansHydrogelsHydrogelsbone tissue engineeringExtra Cellular MatrixHydrogels

Identifiers

PMID29559838
PMCPMC5859772
OpenAlexW2789973994

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.