Evidence map›Paper›PMID 29559782›Full record

ArticleNeuropsychiatric disease and treatment2018

Repetitive transcranial magnetic stimulation for the treatment of cognitive impairment in frontotemporal dementia: an open-label pilot study.

Jakub Antczak, Katarzyna Kowalska, Aleksandra Klimkowicz-Mrowiec, Barbara Wach, Katarzyna Kasprzyk, Marta Banach, Karolina Rzeźnicka-Brzegowy, Jadwiga Kubica, Agnieszka Słowik

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07316413 (Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07316413 narecruitingnot on this mapstarted 2025, after this paper: background citation

Repetitive Transcranial Magnetic Stimulation in Frontotemporal Lobar Degeneration

TypeinterventionalSponsorUniversità degli Studi di BresciaRan2025 to 2029Enrolled120ConditionsFTLD, FTD, bvFTD, PPAArmsTheta burst stimulation, Sham Theta burst stimulation
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  8. Article
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  10. Frontotemporal Dementia, Where Do We Stand? A Narrative Review.International journal of molecular sciences · 2023
    Review
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  14. Article
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  19. Editorial: Nonpharmacological Treatment of Cognitive Impairment.The journal of nutrition, health & aging · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jakub AntczakDepartment of Neurology, Jagiellonian University Medical College, Kraków, Poland.
Katarzyna KowalskaDepartment of Neurology, Jagiellonian University Medical College, Kraków, Poland.
Aleksandra Klimkowicz-MrowiecDepartment of Neurology, Jagiellonian University Medical College, Kraków, Poland.
Barbara WachDepartment of Neurology, 5th Military Hospital with Polyclinic in Cracow, Kraków, Poland.
Katarzyna KasprzykDepartment of Neurology, Jagiellonian University Medical College, Kraków, Poland.
Marta BanachDepartment of Neurology, Jagiellonian University Medical College, Kraków, Poland.
Karolina Rzeźnicka-BrzegowyInstitute of Physiotherapy, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland.
Jadwiga KubicaInstitute of Physiotherapy, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland.
Agnieszka SłowikDepartment of Neurology, Jagiellonian University Medical College, Kraków, Poland.
Jagiellonian University · PLMilitary Hospital · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFrontotemporal dementia (FTD) is one of the most frequent dementia types in patients under 65 years of age. Currently, no therapy can effectively improve the cognitive deficits associated with FTD. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method of inducing brain plasticity with therapeutic potential in neurodegenerative diseases. The purpose of this study was to evaluate the effect of rTMS on cognitive, behavioral, and emotional function in FTD.

methodsNine patients (seven women, four men, mean age 61.7±10.1 years) with the behavioral variant of FTD, one with nonfluent/agrammatic variant primary progressive aphasia, and one with progressive nonfluent aphasia (subtypes of FTD) underwent 10 daily sessions of 10 Hz rTMS over the bilateral dorsolateral prefrontal cortex. Cognitive and behavioral assessments were administered before and after therapy.

resultsAfter rTMS, the Montreal Cognitive Assessment and letter and digit cancellation test scores, as well as reading time and error number in the Stroop test improved. The caregivers' impression of the daily functioning of patients improved in the Frontal Behavioral Inventory scores. These changes were not paralleled by an improvement of mood.

conclusionThe results indicate that rTMS may improve the cognitive performance of patients with FTD and warrant sham-controlled trials.

Indexed as

frontotemporal dementiaMontreal Cognitive Assessmentrepetitive transcranial magnetic stimulation

Identifiers

PMID29559782
PMCPMC5856301
OpenAlexW2791508185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.