ArticleScientific reports2018
Comparative whole-genome sequence analysis of Mycobacterium tuberculosis isolated from tuberculous meningitis and pulmonary tuberculosis patients.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Comparative Genomic Analysis ofTropical medicine and infectious disease · 2024Article
- Diversification of gene content in theMicrobiology spectrum · 2024Article
- Central Nervous System Tuberculosis: Risk Factors for Mortality in a Propensity Score-Matched Case-Control Study.Open forum infectious diseases · 2023Article
- Pangenome Reconstruction ofMicroorganisms · 2023Article
- Metabolomic analysis of Mycobacterium tuberculosis reveals metabolic profiles for identification of drug-resistant tuberculosis.Scientific reports · 2023Article
- Distribution and origins ofMicrobial genomics · 2023Article
- Comparative whole-genome sequence analysis ofFrontiers in microbiology · 2023Article
- Characterization ofFrontiers in immunology · 2023Article
- Article
- A genome epidemiological study of mycobacterium tuberculosis in subpopulations with high and low incidence rate in Guangxi, South China.BMC infectious diseases · 2021Article
- Whole-genome comparative analysis at the lineage/sublineage level discloses relationships betweenPeerJ · 2021Article
- Novel Long Non-coding RNA and LASSO Prediction Model to Better Identify Pulmonary Tuberculosis: A Case-Control Study in China.Frontiers in molecular biosciences · 2021Article
- Application of Pathogen Discovery/Metagenomic Sequencing in CNS HIV.Current HIV/AIDS reports · 2020Review
- Analysis of Tuberculosis Meningitis Pathogenesis, Diagnosis, and Treatment.Journal of clinical medicine · 2020Review
- Review
- Recent Developments in Tuberculous Meningitis Pathogenesis and Diagnostics.Wellcome open research · 2019Review
- Sequencing and Annotation of the Genome of Mycobacterium tuberculosis MYC004, a Strain Causing Meningitis in Mexico.Genome announcements · 2018Article
- Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculous meningitis (TBM) is a severe form of tuberculosis with a high mortality rate. The factors associated with TBM pathogenesis are still unclear. Using comparative whole-genome sequence analysis we compared Mycobacterium tuberculosis (Mtb) isolates from cerebrospinal fluid of TBM cases (n = 73) with those from sputum of pulmonary tuberculosis (PulTB) patients (n = 220) from Thailand. The aim of this study was to seek genetic variants of Mtb associated with TBM. Regardless of Mtb lineage, we found 242 variants that were common to all TBM isolates. Among these variants, 28 were missense SNPs occurring mainly in the pks genes (involving polyketide synthesis) and the PE/PPE gene. Six lineage-independent SNPs were commonly found in TBM isolates, two of which were missense SNPs in Rv0532 (PE_PGRS6). Structural variant analysis revealed that PulTB isolates had 14 genomic regions containing 2-3-fold greater read depth, indicating higher copy number variants and half of these genes belonged to the PE/PPE gene family. Phylogenetic analysis revealed only two small clusters of TBM clonal isolates without support from epidemiological data. This study reported genetic variants of Mtb commonly found in TBM patients compared to PulTB patients. Variants associated with TBM disease warrant further investigation.
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