Evidence map›Paper›PMID 29559670›Full record

ArticleScientific reports2018

Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation.

Fabricio Castro Machado, Caio Haddad Franco, Jose Vitorino Dos Santos Neto, Karina Luiza Dias-Teixeira, Carolina Borsoi Moraes, Ulisses Gazos Lopes, Bertal Huseyin Aktas, Sergio Schenkman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Fabricio Castro MachadoDepartamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, 04039-032, São Paulo, SP, Brazil.
Caio Haddad FrancoDepartamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, 04039-032, São Paulo, SP, Brazil.
Jose Vitorino Dos Santos NetoLaboratório de Parasitologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Karina Luiza Dias-TeixeiraLaboratório de Parasitologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Carolina Borsoi MoraesInstituto Butantan, São Paulo, SP, Brazil.
Ulisses Gazos LopesLaboratório de Parasitologia Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Bertal Huseyin AktasHematology Laboratory for Translational Research, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, United States. huseyin_aktas@hms.harvard.edu.
Sergio SchenkmanDepartamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, 04039-032, São Paulo, SP, Brazil. sschenkman@unifesp.br.ORCID 0000-0001-9353-8480
Universidade Federal do Rio de Janeiro · BRUniversidade Federal de São Paulo · BRBrigham and Women's Hospital · USInstituto Butantan · BRUniversidade de São Paulo · BR

Funding

Targeting Endoplasmic Reticulum Stress Response for Cancer TherapyR01CA152312 · NCI · HARVARD MEDICAL SCHOOL · PI AKTAS, BERTAL H. · 2011 to 2015
$1.8M
NCI NIH HHS R01 CA152312
6 · The paper itself

Abstract

Some 1,3-diarylureas and 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylureas (cHAUs) activate heme-regulated kinase causing protein synthesis inhibition via phosphorylation of the eukaryotic translation initiation factor 2 (eIF2) in mammalian cancer cells. To evaluate if these agents have potential to inhibit trypanosome multiplication by also affecting the phosphorylation of eIF2 alpha subunit (eIF2α), we tested 25 analogs of 1,3-diarylureas and cHAUs against Trypanosoma cruzi, the agent of Chagas disease. One of them (I-17) presented selectivity close to 10-fold against the insect replicative forms and also inhibited the multiplication of T. cruzi inside mammalian cells with an EC

Indexed as

AnimalsCell Line, TumorCell ProliferationChagas DiseaseeIF-2 KinaseEukaryotic Initiation Factor-2G1 PhaseHemeHumansMyoblastsParasitic Sensitivity TestsPhosphorylationProtozoan ProteinsRatsTrypanosoma brucei bruceiTrypanosoma cruzieIF-2 KinaseEukaryotic Initiation Factor-2HemeProtozoan ProteinsUrea

Identifiers

PMID29559670
PMCPMC5861040
OpenAlexW2801874872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.