ArticleScientific reports2018
In vitro effects of hydroxyapatite containing toothpastes on dentin permeability after multiple applications and ageing.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03553966 (Impact of the Daily Use of Hydroxyapatite-toothpaste on the Occurrence of Enamel Caries in the Primary Dentition), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of the Daily Use of Hydroxyapatite-toothpaste on the Occurrence of Enamel Caries in the Primary Dentition (ECIPDEN17)
Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Synergistic efficacy of a biomimetic hydroxyapatite-citrate complex for dentin hypersensitivity: an in vitro and clinical study.BMC oral health · 2026Trial
- Experimental pastes containing niobophosphate and 45S5 bioactive glasses for treatment of dentin hypersensitivity: dentin permeability and tubule obliteration.Clinical oral investigations · 2022Trial
- Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial.Scientific reports · 2021Trial
- Article
- Adjunctive effect of dentifrices on the durability of in-office desensitizing treatment under erosive-abrasive conditions.BMC oral health · 2026Article
- Silver diamine fluoride differentially affects dentin and hypomineralized enamel permeabilities.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Development of Bioactive Niobium Oxalate-Based Desensitizer: Permeability and Formation of Nanoprecursors.Brazilian dental journal · 2025Article
- Effect of an experimental desensitizer with a hydroxyapatite-capsaicin composite applied before in-office dental bleaching on hydrogen peroxide diffusion, color and surface changes.Clinical oral investigations · 2024Article
- Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel.Biomimetics (Basel, Switzerland) · 2023Article
- Oyster shell-derived nano-hydroxyapatite and proanthocyanidin pretreatment on dentinal tubule occlusion and permeability before and after acid challenge-an in vitro study.Journal of materials science. Materials in medicine · 2023Article
- Preliminary comparison of the remineralization and desensitization effects of a novel mineralized ion-releasing toothpaste and commercially available competitive products.Journal of dental sciences · 2023Article
- Biomimetic Mineralized Hydrophilic Polyurethane Primers for Inducing Dentin Tubule Fillings.Polymers · 2022Article
- Adhesion and whitening efficacy of P11-4 self-assembling peptide and HAP suspension after using NaOCl as a pre-treatment agent.BMC oral health · 2022Article
- S-PRG-based toothpastes compared to NaF toothpaste and NaF varnish on dentin permeability in vitro.Journal of applied oral science : revista FOB · 2022Article
- Hydroxyapatite in Oral Care Products-A Review.Materials (Basel, Switzerland) · 2021Review
- Bonding Performance of Universal Adhesives Applied to Nano-Hydroxyapatite Desensitized Dentin Using Etch-and-Rinse or Self-Etch Mode.Materials (Basel, Switzerland) · 2021Article
- Cariogenic Biofilms: Development, Properties, and Biomimetic Preventive Agents.Dentistry journal · 2021Review
- In Vitro Evaluation of Desensitizing Agents Containing Bioactive Scaffolds of Nanofibers on Dentin Remineralization.Materials (Basel, Switzerland) · 2021Article
- The Potential of Hydroxyapatite Toothpaste to Prevent Root Caries: A pH-Cycling Study.Clinical, cosmetic and investigational dentistry · 2021Article
- Whitening Effects of a Novel Oral Care Gel with Biomimetic Hydroxyapatite: A 4-Week Observational Pilot Study.Biomimetics (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This in vitro study evaluated the effect of toothpastes with different active ingredients on dentin permeability using an extended protocol including multiple applications and several thermal ageing cycles in the presence or absence of human saliva. The Null hypothesis was that dentin permeability of a hydroxyapatite containing toothpaste (BR), a potassium nitrate (SP) and an arginine and calcium carbonate (EH) containing toothpaste were similar. Dentin permeability was measured as hydraulic conductance using a commercially available capillary flow system (Flodec, Geneva) and results were expressed as % relative to matching controls. Without saliva, the ranking (best first) of dentin permeability was BR(61%) < SP(87%) < EH(118%), with saliva EH(63%) < SP(72%) < BR(88%). Saliva increased or decreased permeability dependent upon the test material. BR reduced dentin permeability significantly more in absence of saliva, with saliva EH was superior to BR. Repeated material application decreased and thermal ageing increased dentin permeability. The different tooth pastes reduced permeability differently, the best being BR without saliva, the least EH without saliva. The newly introduced test conditions (ageing, saliva, multiple applications) influenced single results significantly, and as they better simulate the in vivo situation they should be considered to be included in further in vitro permeability testing of desensitizing preparations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.