ReviewCritical care (London, England)2018
Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury.
Review in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 58 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Vitamin C on Biomarkers of Neurologic Injury in Patients With Return of Spontaneous Circulation After Out-of-Hospital Cardiac Arrest
Evaluation of the Oxidative Status of Patients Undergoing Solid Organs Transplantation: Observational Study
The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.
Who cites it
58 citing papers in PubMed, 8 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.BMC cardiovascular disorders · 2023Pooled it
- Effect of intravenous vitamin C on adult septic patients: a systematic review and meta-analysis.Frontiers in nutrition · 2023Pooled it
- Impact of intravenous vitamin C as a monotherapy on mortality risk in critically ill patients: A meta-analysis of randomized controlled trials with trial sequential analysis.Frontiers in nutrition · 2023Pooled it
- The effect of intravenous vitamin C on clinical outcomes in patients with sepsis or septic shock: A meta-analysis of randomized controlled trials.Frontiers in nutrition · 2022Pooled it
- Vitamin C May Improve Left Ventricular Ejection Fraction: A Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis.Nutrients · 2019Pooled it
- Pooled it
- cEEG and rEEG detection rates of prognostic indicators in cardiac arrest patients: a systematic review and diagnostic meta-analysis.Frontiers in neurologyPooled it
- Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial.Intensive care medicine · 2026Trial
- Trial
- Addition of Vitamin C Does Not Decrease Neuron-Specific Enolase Levels in Adult Survivors of Cardiac Arrest-Results of a Randomized Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Effect of Intravenous Injection of Vitamin C on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Double-Blind, Randomized Trial.Drug design, development and therapy · 2020Trial
- The Effect of High-Dose Vitamin C on Biochemical Markers of Myocardial Injury in Coronary Artery Bypass Surgery.Brazilian journal of cardiovascular surgery · 2019Trial
- Estimating Vitamin C Status in Critically Ill Patients with a Novel Point-of-Care Oxidation-Reduction Potential Measurement.Nutrients · 2019Trial
- High-dose vitamin C: A promising anti-tumor agent, insight from mechanisms, clinical research, and challenges.Genes & diseases · 2026Review
- Postoperative Delirium and Vitamin C: Rethinking Unfavorable Outcomes Through the Lens of Underdosing.Journal of clinical medicine research · 2025Article
- Neuroprotective effects of vitamin C on hypoxic-ischemic brain injury in neonatal mice.Pediatric research · 2025Article
- Nutritional Support for Necrotizing Soft Tissue Infection Patients: From ICU to Outpatient Care.Journal of clinical medicine · 2025Review
- High-dose intravenous vitamin C reduce C-reactive protein levels, fluid retention, and APACHE II scores in patients with moderately severe acute pancreatitis: a prospective, randomized, double-blinded, placebo-controlled study.Annals of intensive care · 2025Article
- Effect of Ascorbic Acid on the Incidence of Postoperative Delirium Among Elderly Patients Undergoing Cardiovascular Surgery: A Pilot Study.Journal of clinical medicine research · 2025Article
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2018 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901 .
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.