Evidence map›Paper›PMID 29558953›Full record

Trial reportLipids in health and disease2018

Effect of Gum Arabic (Acacia Senegal) supplementation on visceral adiposity index (VAI) and blood pressure in patients with type 2 diabetes mellitus as indicators of cardiovascular disease (CVD): a randomized and placebo-controlled clinical trial.

Rasha Babiker, Khalifa Elmusharaf, Michael B Keogh, Amal M Saeed

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04215380 (Effects of Gum Arabic Ingestion on Hormonal and Metabolic Changes in Patients With Polycystic Ovary Syndrome), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04215380 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effects of Gum Arabic Ingestion on Hormonal and Metabolic Changes in Patients With Polycystic Ovary Syndrome: Two Arm Randomized Double Blind Placebo Controlled Study

TypeinterventionalSponsorLamis KaddamRan2020 to 2020Enrolled60ConditionsPolycystic Ovary SyndromeArmsAcacia Senegal extract, Pectin
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Rasha BabikerDepartment of Physiology, Faculty of Medicine, University of Medical Sciences & Technology, Khartoum, Sudan. rashat33@yahoo.com.ORCID http://orcid.org/0000-0002-9456-2033
Khalifa ElmusharafGraduate Entry Medical School, University of Limerick, Limerick, Ireland.
Michael B KeoghHuman Biology & Research Laboratory Manager, School of Medicine, Royal College of Surgeons in Ireland RCSI-Bahrain, P.O Box 15503, Adliya, Manama, Bahrain.
Amal M SaeedDepartment of Physiology, Faculty of Medicine, University of Khartoum, P.O Box 102, Khartoum, Sudan.
Royal College of Surgeons in Ireland - Bahrain · BHUniversity of Khartoum · SDUniversity of Limerick · IEUniversity of Medical Sciences and Technology · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a strong association between cardiometabolic risk and adipose tissue dysfunction with great consequences on type 2 diabetic patients. Visceral Adiposity Index (VAI) is an indirect clinical marker of adipose tissue dysfunction. Gum Arabic (GA) is a safe dietary fiber, an exudate of Acacia Senegal. Gum Arabic had shown lipid lowering effect in both humans and animals. The aim of this trial was to determine the effect of GA supplementation on anthropometric obesity marker, Visceral Adiposity Index (VAI) and blood pressure in patients with type 2 diabetes mellitus.

methodsThis randomized, double blinded, placebo controlled trial recruited a total of 91 type 2 diabetic patients (73 females, 18 males), age (mean ± SD) 50.09 ± 9.3 years on hypoglycemic agents and were randomly assigned into two groups, either to consume 30 g of GA or 5 g of placebo daily for 3 months. Anthropometric obesity markers were measured and indices were calculated. Blood pressure was measured and high density lipoprotein (HDL) and triglycerides (TG) were determined in fasting blood samples at the start and end of the study period.

resultsAfter intervention, Gum Arabic decreased BMI and VAI significantly (P < 0.05) in GA group by 2 and 23.7% respectively. Body adiposity index significantly decreased by 3.9% in GA group while there were no significant changes in waist circumference or waist-to-hip ratio (WHR). Systolic blood pressure significantly decreased by 7.6% in GA group and by 2.7% in placebo group from baseline with no significant changes in diastolic blood pressure in the two groups.

conclusionGum Arabic consumption at a dose of 30 g/d for 3 months may play an effective role in preventing weight gain and modulating adipose tissue dysfunction in type 2 diabetic patients, although no effect has been shown in waist-to-hip ratio.

trial registrationThe trial had been registered as prospective interventional clinical trials in the Pan African Clinical Trial Registry (PACTR) PACTR201403000785219 , on 7th March 2014.

Indexed as

AdiposityAdultBlood PressureBody Mass IndexCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleGum ArabicHumansHypoglycemic AgentsMaleMiddle AgedGum ArabicHypoglycemic AgentsBMI and blood pressureGum ArabicLipid profileNutritionType 2 diabetes mellitusVAI

Identifiers

PMID29558953
PMCPMC5859434
OpenAlexW2794932225

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.