ArticleThe American journal of psychiatry2018
Developmental Trajectories of the Orbitofrontal Cortex and Anhedonia in Middle Childhood and Risk for Substance Use in Adolescence in a Longitudinal Sample of Depressed and Healthy Preschoolers.
Article in The American journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.Clinical psychology review · 2020Pooled it
- Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies.Developmental cognitive neuroscience · 2019Pooled it
- Establishing a transdiagnostic dimension of early childhood depressive symptoms using the Preschool Feelings Checklist-Scale.JCPP advances · 2026Article
- Neonatal striatal volume is associated with infant anhedonia.Journal of affective disorders · 2026Article
- Environmental, Health, and Psychological Factors Predict Alcohol Sipping in Childhood: A Machine Learning Analysis of the ABCD Study.JAACAP open · 2025Article
- Identification and External Validation of a Problem Cannabis Risk Network.Biological psychiatry · 2025Article
- A Systematic Review: Investigating Biomarkers of Anhedonia and Amotivation in Depression and Cannabis Use.JAACAP open · 2025Review
- Predicting the onset of internalizing disorders in early adolescence using deep learning optimized with AI.Frontiers in psychiatry · 2025Article
- Article
- Genetic Associations of Anhedonia: Insights into Overlap of Mental and Somatic Disorders.Consortium psychiatricum · 2024Article
- Alcohol use and grey matter structure: Disentangling predispositional and causal contributions in human studies.Addiction biology · 2023Review
- Article
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- Effects of Parental Internalizing and Externalizing Behavior Problems on Children's Limbic Brain Structures-An MRI Study.Brain sciences · 2022Article
- Neural cognitive control moderates the longitudinal link between hedonia and substance use across adolescence.Developmental cognitive neuroscience · 2022Article
- Learning it the hard way - how enjoying life and positive appraisal buffer the negative effects of stressors on mental health in the COVID-19 pandemic.Journal of affective disorders reports · 2021Article
- Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Functional connectivity in frontostriatal networks differentiate offspring of parents with substance use disorders from other high-risk youth.Drug and alcohol dependence · 2021Article
- State Anhedonia in Young Healthy Adults: Psychometric Properties of the German Dimensional Anhedonia Rating Scale (DARS) and Effects of the COVID-19 Pandemic.Frontiers in psychology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveDeficits in reward processing are established in mood and substance use disorders and are known risk factors for these disorders. Volume reductions of the orbitofrontal cortex and the striatum, regions that subserve neural response to reward, have been shown to be related to anhedonia in depressive and substance use disorders. The authors sought to investigate how structural maturation of these regions in childhood varies with level of anhedonia and predicts later substance use.
methodThe study employed data from a sample of depressed and healthy preschoolers studied longitudinally that included three waves of neuroimaging from school age to adolescence. Three years after scan 3, at ages 13-18, participants underwent a comprehensive behavioral and substance use assessment. Multilevel modeling was used to investigate the relationship between anhedonia and the growth trajectories of the striatum and orbitofrontal cortex. Zero-inflated Poisson regression models were then used to determine whether the intercepts and slopes of these trajectories predicted later alcohol and marijuana use frequency in adolescence.
resultsThe anhedonia-by-age interaction was significant in the multilevel modeling of orbitofrontal cortical but not striatal volume. Higher anhedonia ratings were significantly associated with steeper decline in orbitofrontal cortical volume with age. Orbitofrontal cortical volume and thickness at age 12 and trajectory over time significantly and negatively predicted subsequent alcohol and marijuana use frequency but not depression during adolescence.
conclusionsThe findings suggest that the development of the orbitofrontal cortex during childhood is strongly linked to experiences of anhedonia and that these growth trajectories predict substance use during a developmentally critical period.
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