Evidence map›Paper›PMID 29558674›Full record

ArticleDrug and alcohol dependence2018

Age sensitive associations of adolescent substance use with amygdalar, ventral striatum, and frontal volumes in young adulthood.

Michael Windle, Joshua C Gray, Karlo Mankit Lei, Allen W Barton, Gene Brody, Steven R H Beach, Adrianna Galván, James MacKillop, Uraina S Clark, Lawrence H Sweet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Bidirectional links between adolescent brain function and substance use moderated by cognitive control.Journal of child psychology and psychiatry, and allied disciplines · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael WindleDepartment of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, United States. Electronic address: mwindle@emory.edu.
Joshua C GrayDepartment of Psychology, University of Georgia, Athens, United States.
Karlo Mankit LeiCenter for Family Research, University of Georgia, Athens, United States.
Allen W BartonCenter for Family Research, University of Georgia, Athens, United States.
Gene BrodyCenter for Family Research, University of Georgia, Athens, United States.
Steven R H BeachCenter for Family Research, University of Georgia, Athens, United States.
Adrianna GalvánDepartment of Psychology, University of California, Los Angeles, United States.
James MacKillopPeter Boris Centre for Addictions Research, McMaster University, Hamilton, Ontario, Canada.
Uraina S ClarkMt. Sinai Hospital, New York, United States.
Lawrence H SweetDepartment of Psychology, University of Georgia, Athens, United States.

Funding

Vulnerability to Drug Use & HIV: Advancing Prevention for Rural African AmericansP30DA027827 · NIDA · UNIVERSITY OF GEORGIA · PI BRODY, GENE H. · 2009 to 2018
$10.2M
The Development of Alcohol Use and Alcohol Disorders Across the LifespanK05AA021143 · NIAAA · EMORY UNIVERSITY · PI WINDLE, MICHAEL T · 2012 to 2016
$1.0M
Effects of Early-Life Stress on Brain Dysfunction in HIV+ Adults: An fMRI StudyK23MH096628 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CLARK, URAINA S. · 2012 to 2017
$875k
NIAAA NIH HHS K05 AA021143NIDA NIH HHS P30 DA027827NIMH NIH HHS K23 MH096628
6 · The paper itself

Abstract

introductionThis study evaluated an age sensitive model of substance use across adolescence to determine if substance use was associated with smaller volumes for an earlier developing brain region, the amygdala, a later developing region, the inferior frontal gyrus, and the ventral striatum.

methodParticipants (N = 110) were African American young adults who were members of a longitudinal cohort across childhood and adolescence. Measures of substance use were collected across early (ages 12-15 yrs.), middle (ages 16-18 yrs.), and later (ages 19-21 yrs.) adolescence; then, at age 25, a representative subset of the sample completed magnetic resonance imaging (MRI) that assessed regional brain volumes.

resultsHigher levels of substance use during early adolescence, but not middle or later adolescence, were significantly associated with smaller amygdalar volume in young adulthood. Higher levels of substance use during middle adolescence, but not early or later adolescence, were significantly associated with smaller pars opercularis volume. Substance use was not associated with the pars triangularis or ventral striatum.

conclusionThese findings support age sensitive associations between substance use and smaller gray matter volumes at age 25 and are consistent with literature supporting the differential nature of substance use and brain maturation across adolescence and into young adulthood.

Indexed as

AdolescentAgingAmygdalaBlack or African AmericanChildChild AbuseCohort StudiesDepressionFemaleFrontal LobeHumansLongitudinal StudiesMagnetic Resonance ImagingMaleSubstance-Related DisordersVentral StriatumAge sensitive developmentAmygdalaPars opercularisStructural neuroimagingSubstance useVentral striatum

Identifiers

PMID29558674
PMCPMC5911233

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.