Evidence map›Paper›PMID 29558518›Full record

SynthesisPloS one2018

Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.

Vanesa Bellou, Lazaros Belbasis, Ioanna Tzoulaki, Evangelos Evangelou

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06330727 (Effects of Three-Month Coffee Consumption on Metabolic Biomarkers in Adults With Prediabetes and Obesity), which is not on this map. Cited by 352 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
352citing papers in PubMed, 22 pooled it
56.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06330727 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effects of Three-Month Coffee Consumption on Metabolic Biomarkers in Adults With Prediabetes and Obesity: a Randomized, Double-blind, Placebo-controlled Clinical Trial

TypeinterventionalSponsorNanjing First Hospital, Nanjing Medical UniversityRan2024 to 2024Enrolled100ConditionsPrediabetesArmsCoffee capsule, Corn starch capsule
3 · Its place in the literature

Who cites it

352 citing papers in PubMed, 22 syntheses or guidelines pooled it, 705 citations in OpenAlex.

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  10. Antibiotics in periodontal treatment: an umbrella review.Frontiers in cellular and infection microbiology · 2025
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292 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Vanesa BellouDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Lazaros BelbasisDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Ioanna TzoulakiDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Evangelos EvangelouDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.ORCID 0000-0002-5488-2999
University of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2DM) is a global epidemic associated with increased health expenditure, and low quality of life. Many non-genetic risk factors have been suggested, but their overall epidemiological credibility has not been assessed.

methodsWe searched PubMed to capture all meta-analyses and Mendelian randomization studies for risk factors of T2DM. For each association, we estimated the summary effect size, its 95% confidence and prediction interval, and the I2 metric. We examined the presence of small-study effects and excess significance bias. We assessed the epidemiological credibility through a set of predefined criteria.

resultsWe captured 86 eligible papers (142 associations) covering a wide range of biomarkers, medical conditions, and dietary, lifestyle, environmental and psychosocial factors. Adiposity, low hip circumference, serum biomarkers (increased level of alanine aminotransferase, gamma-glutamyl transferase, uric acid and C-reactive protein, and decreased level of adiponectin and vitamin D), an unhealthy dietary pattern (increased consumption of processed meat and sugar-sweetened beverages, decreased intake of whole grains, coffee and heme iron, and low adherence to a healthy dietary pattern), low level of education and conscientiousness, decreased physical activity, high sedentary time and duration of television watching, low alcohol drinking, smoking, air pollution, and some medical conditions (high systolic blood pressure, late menarche age, gestational diabetes, metabolic syndrome, preterm birth) presented robust evidence for increased risk of T2DM.

conclusionsA healthy lifestyle pattern could lead to decreased risk for T2DM. Future randomized clinical trials should focus on identifying efficient strategies to modify harmful daily habits and predisposing dietary patterns.

Indexed as

Life StyleAir PollutionDiabetes Mellitus, Type 2DietExerciseHumansObesityRisk Factors

Identifiers

PMID29558518
PMCPMC5860745
OpenAlexW2789317488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.