ArticlePLoS biology2018
Inflammation arising from obesity reduces taste bud abundance and inhibits renewal.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 154 citations in OpenAlex.
- No significant salt or sweet taste preference or sensitivity differences following ad libitum consumption of ultra-processed and unprocessed diets: a randomized controlled pilot study.Chemical senses · 2023Trial
- Converging Signaling Networks Drive Taste Bud Morphogenesis, Turnover, and Regeneration.International journal of molecular sciences · 2026Review
- Lack of Structural Change in Olfactory Circuitry Following Fecal Microbiome Transplant From Donors Subjected to Diet-induced Obesity.Journal of neurochemistry · 2026Article
- Emerging Role of Taste Receptors, Entero-Endocrine Cells in Type 2 Diabetes and Metabolic Disorders.Nutrients · 2026Review
- Article
- Taste receptor downregulation in diet-induced obesity reveals circumvallate papillae-specific taste-inflammatory networks.Frontiers in nutrition · 2026Article
- Systemic inflammation as a mediator between food preferences and metabolic syndrome: a cross-sectional study.Frontiers in nutrition · 2026Article
- High physical activity is associated with decreased fungiform papillae area and number, elevated sucrose recognition thresholds, and increased IL-6 levels: an observational human study.Nutrition & metabolism · 2025Article
- Reduced Fat Taste Sensitivity and Its Association with Childhood Obesity in Tunisian Children: A Cross-Sectional Study.Nutrients · 2025Article
- Effects of high-fat and low-calcium diets on the structure of filiform and fungiform tongue papillae in rats.Scientific reports · 2025Article
- Self-Administered Taste Testing Without Water: Normative Data for the 53-Item Waterless Empirical Taste Test (WETT).International forum of allergy & rhinology · 2025Article
- Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery.Obesity (Silver Spring, Md.) · 2025Article
- The Role of Diet and Hormones on Taste: Low Carb Compared With Low Fat Study Findings.Current developments in nutrition · 2025Article
- Expression and structural analysis of taste receptor genes in Iberian and Duroc pigs.Genetics, selection, evolution : GSE · 2025Article
- Taste Plasticity in Nutrition and Health: A Scoping Review.Nutrients · 2025Article
- Bitter and Sweet Diets Alter Taste Response and Alcohol Consumption Behavior in Mice.Nutrients · 2025Article
- Potential role of glucagon like peptide 1 in taste receptors.Frontiers in endocrinology · 2025Review
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2025Review
- Article
- Diet-Induced Obesity Induces Transcriptomic Changes in Neuroimmunometabolic-Related Genes in the Striatum and Olfactory Bulb.International journal of molecular sciences · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite evidence that the ability to taste is weakened by obesity and can be rescued with weight loss intervention, few studies have investigated the molecular effects of obesity on the taste system. Taste bud cells undergo continual turnover even in adulthood, exhibiting an average life span of only a few weeks, tightly controlled by a balance of proliferation and cell death. Recent data reveal that an acute inflammation event can alter this balance. We demonstrate that chronic low-grade inflammation brought on by obesity reduces the number of taste buds in gustatory tissues of mice-and is likely the cause of taste dysfunction seen in obese populations-by upsetting this balance of renewal and cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.