Evidence map›Paper›PMID 29558444›Full record

ArticleNutrients2018

Beneficial Effect of Jojoba Seed Extracts on Hyperglycemia-Induced Oxidative Stress in RINm5f Beta Cells.

Sahla Belhadj, Olfa Hentati, Ghaith Hamdaoui, Khaskhoussi Fakhreddine, Elisa Maillard, Stéphanie Dal, Séverine Sigrist

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sahla BelhadjUMR DIATHEC, EA 7294, Fédération de Médecine Translationnelle de Strasbourg (FMTS), University of Strasbourg, Boulevard René Leriche, 67200 Strasbourg, France. belhadjsahla@hotmail.com.
Olfa HentatiInstitut Supérieur de Biotechnologie de Sfax (ISBS), Road of Soukra Km 4, PO Box, Sfax 1175, Tunisia. olfa_hentati@yahoo.fr.
Ghaith HamdaouiLaboratory of Bioactive Substances, Center of Biotechnology of Borj Cédria, BP 901, Hammam-lif 2050, Tunisia. ghaith_cbbc@yahoo.fr.
Khaskhoussi FakhreddineAGRO-CRC, Al Amine Al Abbassi Street, Tunis 1002, Tunisia. khaskhoussif@yahoo.fr.
Elisa MaillardUMR DIATHEC, EA 7294, Fédération de Médecine Translationnelle de Strasbourg (FMTS), University of Strasbourg, Boulevard René Leriche, 67200 Strasbourg, France. e.pedracini@ceed-diabete.org.
Stéphanie DalUMR DIATHEC, EA 7294, Fédération de Médecine Translationnelle de Strasbourg (FMTS), University of Strasbourg, Boulevard René Leriche, 67200 Strasbourg, France. dalstephaniepro67@gmail.com.
Séverine SigristUMR DIATHEC, EA 7294, Fédération de Médecine Translationnelle de Strasbourg (FMTS), University of Strasbourg, Boulevard René Leriche, 67200 Strasbourg, France. s.sigrist@ceed-diabete.org.
Université de Strasbourg · FRCenter of Biotechnogy of Borj Cédria · TNInstitut Supérieur de Biotechnologie de Sfax · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperglycemia occurs during diabetes and insulin resistance. It causes oxidative stress by increasing reactive oxygen species (ROS) levels, leading to cellular damage. Polyphenols play a central role in defense against oxidative stress. In our study, we investigated the antioxidant properties of simmondsin, a pure molecule present in jojoba seeds, and of the aqueous extract of jojoba seeds on fructose-induced oxidative stress in RINm5f beta cells. The exposure of RINm5f beta cells to fructose triggered the loss of cell viability (-48%,

Indexed as

MagnoliopsidaSeedsAcetonitrilesAnimalsAntioxidantsCaspase 3Cell Line, TumorCell SurvivalCyclohexanesDose-Response Relationship, DrugFructoseGlucosidesInsulinInsulin-Secreting CellsInsulin SecretionNADPH OxidasesAcetonitrilesAntioxidantsCasp3 protein, ratCaspase 3Cyba protein, ratCyclohexanesFructoseGlucosidesInsulinNADPH OxidasesNfe2l2 protein, ratNF-E2-Related Factor 2Plant ExtractsReactive Oxygen Speciessimmondsincaspase-3jojobaNrf2oxidative stressp22phoxRINm5f

Identifiers

PMID29558444
PMCPMC5872802
OpenAlexW2792216333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.