Evidence map›Paper›PMID 29558439›Full record

ArticleMolecules (Basel, Switzerland)2018

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols.

Patrick Weber, Seyed A Nasseri, Bettina M Pabst, Ana Torvisco, Philipp Müller, Eduard Paschke, Marion Tschernutter, Werner Windischhofer, Stephen G Withers, Tanja M Wrodnigg and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Patrick WeberGlycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria. patrick.weber@tugraz.at.
Seyed A NasseriChemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada. snasseri@chem.ubc.ca.
Bettina M PabstLaboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria. bettina.pabst@medunigraz.at.
Ana TorviscoInstitute of Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria. ana.torviscogomez@tugraz.at.
Philipp MüllerInstitute of Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria. philipp.mueller@tugraz.at.
Eduard PaschkeLaboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria. eduard.paschke@inode.at.
Marion TschernutterLaboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria. marion.tschernutter@medunigraz.at.ORCID 0000-0002-7494-1896
Werner WindischhoferLaboratory of Metabolic Diseases, Department of Pediatrics, MedUni Graz, Auenbruggerplatz 30, A-8036 Graz, Austria. werner.windischhofer@medunigraz.at.
Stephen G WithersChemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada. withers@chem.ubc.ca.ORCID 0000-0002-6722-5701
Tanja M WrodniggGlycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria. t.wrodnigg@tugraz.at.
Arnold E StützGlycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010 Graz, Austria. stuetz@tugraz.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From 1,2;3,4-di-

Indexed as

beta-N-AcetylhexosaminidasesCrystallography, X-RayCyclopentanesEnzyme InhibitorsMolecular Conformationbeta-N-AcetylhexosaminidasesCyclopentanesEnzyme Inhibitorsaminocyclopentane">d-hexosaminidase inhibitorN-acetyl-Tay-Sachs

Identifiers

PMID29558439
PMCPMC6017319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.