Evidence map›Paper›PMID 29558430›Full record

ArticleInternational journal of molecular sciences2018

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters.

Hüseyin Ilgü, Jean-Marc Jeckelmann, Claire Colas, Zöhre Ucurum, Avner Schlessinger, Dimitrios Fotiadis

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Function and Regulation of Acid Resistance Antiporters.The Journal of membrane biology · 2019
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Frontiers in chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hüseyin IlgüInstitute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, CH-3012 Bern, Switzerland. hueseyin.ilgue@ibmm.unibe.ch.
Jean-Marc JeckelmannInstitute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, CH-3012 Bern, Switzerland. jean-marc.jeckelmann@ibmm.unibe.ch.
Claire ColasDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. claire.colas@gmail.com.
Zöhre UcurumInstitute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, CH-3012 Bern, Switzerland. zoehre.ucurum@ibmm.unibe.ch.
Avner SchlessingerDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. avner.schlessinger@mssm.edu.
Dimitrios FotiadisInstitute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, CH-3012 Bern, Switzerland. dimitrios.fotiadis@ibmm.unibe.ch.
University of Bern · CHIcahn School of Medicine at Mount Sinai · US

Funding

Substrate Specificity Determinants in Nutrient Solute Carrier TransportersR01GM108911 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCHLESSINGER, AVNER · 2014 to 2022
$3.1M
NIGMS NIH HHS R01 GM108911
6 · The paper itself

Abstract

The l-arginine/agmatine transporter AdiC is a prokaryotic member of the SLC7 family, which enables pathogenic enterobacteria to survive the extremely acidic gastric environment. Wild-type AdiC from

Indexed as

Molecular Dynamics SimulationMutationProtein StabilityAmino Acid Transport SystemsAntiportersEscherichia coli ProteinsHot TemperatureHumansLarge Neutral Amino Acid-Transporter 1LigandsProtein BindingSequence HomologyAdiC protein, E coliAmino Acid Transport SystemsAntiportersEscherichia coli ProteinsLarge Neutral Amino Acid-Transporter 1Ligandsacid resistanceAdiCcancer metabolismenterobacteria">l-arginine/agmatine transporterLAT1">l-type amino acid transportermelting temperaturethermostability

Identifiers

PMID29558430
PMCPMC5877779
OpenAlexW2791010701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.