Evidence map›Paper›PMID 29558383›Full record

SynthesisNutrients2018

Effect of Zinc Supplementation on Growth Outcomes in Children under 5 Years of Age.

Enju Liu, Laura Pimpin, Masha Shulkin, Sarah Kranz, Christopher P Duggan, Dariush Mozaffarian, Wafaie W Fawzi

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Trial
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  10. Article
  11. The gut microbiota in malnutrition.Nature reviews. Microbiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Enju LiuInstitutional Centers of Clinical and Translational Research, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA. Enju.Liu@childrens.harvard.edu.
Laura PimpinFriedman School of Nutrition Science and Policy, Tufts University, 150 Harrison Ave, Boston, MA 02111, USA. laura.pimpin@gmail.com.
Masha ShulkinFriedman School of Nutrition Science and Policy, Tufts University, 150 Harrison Ave, Boston, MA 02111, USA. shulkinm@gmail.com.
Sarah KranzFriedman School of Nutrition Science and Policy, Tufts University, 150 Harrison Ave, Boston, MA 02111, USA. Sarah.Kranz@tufts.edu.
Christopher P DugganDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA. christopher.duggan@childrens.harvard.edu.
Dariush MozaffarianFriedman School of Nutrition Science and Policy, Tufts University, 150 Harrison Ave, Boston, MA 02111, USA. Dariush.Mozaffarian@tufts.edu.
Wafaie W FawziDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA. mina@hsph.harvard.edu.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24DK104676 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2015 to 2019
$903k
NIDDK NIH HHS K24 DK104676NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

(1) Background: The effects of zinc supplementation on child growth, and prior reviews of these studies, have shown mixed results. We aim to systematically review and meta-analyze randomized controlled trials evaluating effects of preventive zinc supplementation for 3 months or longer during pregnancy or in children up to age 5 years on pregnancy outcomes and child growth; (2) Methods: We searched PubMed, EMBASE, Cochrane Library, Web of Science, and trial registries for eligible trials up to October 10, 2017. Inclusion selection and data extractions were performed independently and in duplicate. Study quality was evaluated by the Cochrane Risk of Bias tool. Findings were pooled using random effects meta-analysis, with heterogeneity assessed by

Indexed as

Child DevelopmentChild Nutritional Physiological PhenomenaDietary SupplementsNutritional StatusAge FactorsBody HeightChild, PreschoolFemaleGestational AgeHumansInfantInfant, NewbornMaleMaternal Nutritional Physiological PhenomenaPregnancyPrenatal CareZincchild growthmeta-analysisrandomized controlled trialsystematic reviewzinc supplementation

Identifiers

PMID29558383
PMCPMC5872795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.