Trial reportNeuropsychological rehabilitation2020
Frontal lesions predict response to prism adaptation treatment in spatial neglect: A randomised controlled study.
Trial report in Neuropsychological rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04966000 (Development of a Neuroimaging Biomarker to Identify Optimal Candidates for Prism Adaptation Treatment), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of a Neuroimaging Biomarker to Identify Optimal Candidates for Prism Adaptation Treatment
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Short-term effect of prism adaptation treatment on severity of unilateral spatial neglect following right hemispheric stroke: a systematic review and meta-analysis.Journal of rehabilitation medicine · 2025Pooled it
- Non-pharmacological interventions for spatial neglect or inattention following stroke and other non-progressive brain injury.The Cochrane database of systematic reviews · 2021Pooled it
- A study of prisms and therapy in attention loss after stroke (SPATIAL): A feasibility randomised controlled trial.Clinical rehabilitation · 2023Trial
- Spatial exploration strategy training for spatial neglect: A pilot study.Neuropsychological rehabilitation · 2022Trial
- Prism adaptation treatment to address spatial neglect in an intensive rehabilitation program: A randomized pilot and feasibility trial.PloS one · 2021Trial
- Resilience of Neural Networks Underlying the Stroop Effect in the Aftermath of Severe COVID-19: fMRI Pilot Study.Brain sciences · 2025Article
- Does prism adaptation treatment reduce spatial neglect and improve function?Frontiers in rehabilitation sciences · 2025Review
- Advances in Stroke Neurorehabilitation.Journal of clinical medicine · 2023Review
- The Neurophysiological Features Associated with Unilateral Spatial Neglect Recovery: A Scoping Review.Brain topography · 2023Article
- Virtual reality-based sensorimotor adaptation shapes subsequent spontaneous and naturalistic stimulus-driven brain activity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Spatial neglect treatment: The brain's spatial-motor Aiming systems.Neuropsychological rehabilitation · 2022Review
- Choosing Sides: Impact of Prismatic Adaptation on the Lateralization of the Attentional System.Frontiers in psychology · 2022Review
- Prism Adaptation Treatment of Spatial Neglect: Feasibility During Inpatient Rehabilitation and Identification of Patients Most Likely to Benefit.Frontiers in neurology · 2022Article
- The Implementation Process of Two Evidence-Based Protocols: A Spatial Neglect Network Initiative.Frontiers in health services · 2022Article
- Spatial Neglect and Anosognosia After Right Brain Stroke.Continuum (Minneapolis, Minn.) · 2021Review
- Prism Adaptation and Optokinetic Stimulation Comparison in the Rehabilitation of Unilateral Spatial Neglect.Brain sciences · 2021Article
- Neural Mechanisms of Prism Adaptation in Healthy Adults and Individuals with Spatial Neglect after Unilateral Stroke: A Review of fMRI Studies.Brain sciences · 2021Review
- Prism Adaptation Treatment Improves Inpatient Rehabilitation Outcome in Individuals With Spatial Neglect: A Retrospective Matched Control Study.Archives of rehabilitation research and clinical translation · 2021Article
- The Effects of Continuous vs. Intermittent Prism Adaptation Protocols for Treating Visuospatial Neglect: A Randomized Controlled Trial.Frontiers in neurology · 2021Article
- Hand Focused Upper Extremity Rehabilitation in the Subacute Phase Post-stroke Using Interactive Virtual Environments.Frontiers in neurology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Spatial neglect commonly follows right hemisphere stroke. It is defined as impaired contralesional stimulus detection, response, or action, causing functional disability. While prism adaptation treatment is highly promising to promote functional recovery of spatial neglect, not all individuals respond. Consistent with a primary effect of prism adaptation on spatial movements, we previously demonstrated that functional improvement after prism adaptation treatment is linked to frontal lobe lesions. However, that study was a treatment-only study with no randomised control group. The current study randomised individuals with spatial neglect to receive 10 days of prism adaptation treatment or to receive only standard care (control group). Replicating our earlier results, we found that the presence of frontal lesions moderated response to prism adaptation treatment: among prism-treated patients, only those with frontal lesions demonstrated functional improvements in their neglect symptoms. Conversely, among individuals in the standard care control group, the presence of frontal lesions did not modify recovery. These results suggest that further research is needed on how frontal lesions may predict response to prism adaptation treatment. Additionally, the results help elucidate the neural network involved in spatial movement and could be used to aid decisions about treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.