Evidence map›Paper›PMID 29558201›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Inhibition of hypoxia-associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria.

Marcele F Bastos, Ana Carolina A V Kayano, João Luiz Silva-Filho, João Conrado K Dos-Santos, Carla Judice, Yara C Blanco, Nathaniel Shryock, Michelle K Sercundes, Luana S Ortolan, Carolina Francelin and 17 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  3. Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair.International journal of molecular sciences · 2021
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 6 institutions in 3 countries.

Marcele F BastosDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
Ana Carolina A V KayanoDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
João Luiz Silva-FilhoDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
João Conrado K Dos-SantosDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
Carla JudiceDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
Yara C BlancoDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
Nathaniel ShryockCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Michelle K SercundesDepartment of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, Brazil.
Luana S OrtolanDepartment of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, Brazil.
Carolina FrancelinDepartment of Functional and Structural Biology, University of Campinas, Campinas, Brazil.
Juliana A LeiteDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
Rafaella OliveiraInstituto Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus, Brazil.
Rosa M EliasDepartment of Immunology, University of São Paulo, São Paulo, Brazil.
Niels O S CâmaraDepartment of Immunology, University of São Paulo, São Paulo, Brazil.
Stefanie C P LopesDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
Letusa AlbrechtDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
Alessandro S FariasDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
Cristina P VicenteDepartment of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, Brazil.
Claudio C WerneckDepartment of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil.
Selma GiorgioDepartment of Animal Biology, University of Campinas, Campinas, Brazil.
Liana VerinaudDepartment of Functional and Structural Biology, University of Campinas, Campinas, Brazil.
Sabrina EpiphanioDepartment of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, Brazil.
Claudio R F MarinhoDepartment of Parasitology, University of São Paulo, São Paulo, Brazil.
Pritesh LalwaniInstituto Leônidas e Maria Deane, Fundação Oswaldo Cruz, Manaus, Brazil.
Rogerio AminoUnit of Malaria Infection and Immunity, Institut Pasteur, Paris, France.
Julio AlibertiCincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Fabio T M CostaDepartment of Genetics, Evolution, Microbiology, and Immunology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, University of Campinas, Campinas, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade de São Paulo · BRFundação Oswaldo Cruz · BRCincinnati Children's Hospital Medical Center · USFundação Carlos Chagas · BRInstitut Pasteur · FR

Funding

Lipoxins and control of inflammation during cerebral malariaR21AI118302 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI ALIBERTI, JULIO · 2015 to 2016
$429k
NIAID NIH HHS R21 AI118302
6 · The paper itself

Abstract

Cerebral malaria (CM) is a multifactorial syndrome involving an exacerbated proinflammatory status, endothelial cell activation, coagulopathy, hypoxia, and accumulation of leukocytes and parasites in the brain microvasculature. Despite significant improvements in malaria control, 15% of mortality is still observed in CM cases, and 25% of survivors develop neurologic sequelae for life-even after appropriate antimalarial therapy. A treatment that ameliorates CM clinical signs, resulting in complete healing, is urgently needed. Previously, we showed a hyperbaric oxygen (HBO)-protective effect against experimental CM. Here, we provide molecular evidence that HBO targets brain endothelial cells by decreasing their activation and inhibits parasite and leukocyte accumulation, thus improving cerebral microcirculatory blood flow. HBO treatment increased the expression of aryl hydrocarbon receptor over hypoxia-inducible factor 1-α (HIF-1α), an oxygen-sensitive cytosolic receptor, along with decreased indoleamine 2,3-dioxygenase 1 expression and kynurenine levels. Moreover, ablation of HIF-1α expression in endothelial cells in mice conferred protection against CM and improved survival. We propose that HBO should be pursued as an adjunctive therapy in CM patients to prolong survival and diminish deleterious proinflammatory reaction. Furthermore, our data support the use of HBO in therapeutic strategies to improve outcomes of non-CM disorders affecting the brain.-Bastos, M. F., Kayano, A. C. A. V., Silva-Filho, J. L., Dos-Santos, J. C. K., Judice, C., Blanco, Y. C., Shryock, N., Sercundes, M. K., Ortolan, L. S., Francelin, C., Leite, J. A., Oliveira, R., Elias, R. M., Câmara, N. O. S., Lopes, S. C. P., Albrecht, L., Farias, A. S., Vicente, C. P., Werneck, C. C., Giorgio, S., Verinaud, L., Epiphanio, S., Marinho, C. R. F., Lalwani, P., Amino, R., Aliberti, J., Costa, F. T. M. Inhibition of hypoxia-associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria.

Indexed as

AnimalsBrainCerebrovascular CirculationEndothelial CellsFemaleHyperbaric OxygenationHypoxiaHypoxia-Inducible Factor 1, alpha SubunitKynurenineMalaria, CerebralMiceMice, Inbred C57BLMicrocirculationOxygenHypoxia-Inducible Factor 1, alpha SubunitKynurenineOxygenaryl-hydrocarbon receptorbrainendothelial cell activationtryptophan metabolism

Identifiers

PMID29558201
PMCPMC6044055
OpenAlexW2791591271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.