Evidence map›Paper›PMID 29558126›Full record

ArticleJournal of medicinal chemistry2018

Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y

Sean Conroy, Nicholas D Kindon, Jacqueline Glenn, Leigh A Stoddart, Richard J Lewis, Stephen J Hill, Barrie Kellam, Michael J Stocks

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Therapeutic potential for P2YPurinergic signalling · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. NanoBRET: The Bright Future of Proximity-Based Assays.Frontiers in bioengineering and biotechnology · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sean ConroySchool of Pharmacy, Centre for Biomolecular Sciences , University Park Nottingham , Nottingham NG7 2RD , U.K.
Nicholas D KindonSchool of Pharmacy, Centre for Biomolecular Sciences , University Park Nottingham , Nottingham NG7 2RD , U.K.
Jacqueline GlennDivision of Physiology, Pharmacology & Neuroscience, Medical School , University of Nottingham , Nottingham NG7 2UH , U.K.
Leigh A StoddartDivision of Physiology, Pharmacology & Neuroscience, Medical School , University of Nottingham , Nottingham NG7 2UH , U.K.
Richard J LewisMedicinal Chemistry, Respiratory, Inflammation and Autoimmunity, IMED Biotech Unit , AstraZeneca , Mölndal, Gothenburg 431 83 , Sweden.
Stephen J HillDivision of Physiology, Pharmacology & Neuroscience, Medical School , University of Nottingham , Nottingham NG7 2UH , U.K.
Barrie KellamSchool of Pharmacy, Centre for Biomolecular Sciences , University Park Nottingham , Nottingham NG7 2RD , U.K.ORCID 0000-0003-0030-9908
Michael J StocksSchool of Pharmacy, Centre for Biomolecular Sciences , University Park Nottingham , Nottingham NG7 2RD , U.K.ORCID 0000-0003-3046-137X
University of Nottingham · GBAstraZeneca (Sweden) · SE

Funding

Medical Research Council MR/L016389/1Medical Research Council MR/N020081/1
6 · The paper itself

Abstract

The human P2Y

Indexed as

AstrocytomaCell LineDibenzocycloheptenesFluorescent DyesHumansLigandsMicroscopy, ConfocalMolecular ProbesProtein BindingPurinergic P2 Receptor AntagonistsPyrimidinonesReceptors, Purinergic P2Y2Recombinant ProteinsStructure-Activity RelationshipAR-C118925DibenzocycloheptenesFluorescent DyesLigandsMolecular ProbesPurinergic P2 Receptor AntagonistsPyrimidinonesReceptors, Purinergic P2Y2Recombinant Proteins

Identifiers

PMID29558126
PMCPMC6026847
OpenAlexW2793116285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.