Evidence map›Paper›PMID 29557854›Full record

Trial reportJournal of acquired immune deficiency syndromes (1999)2018

Cost and Cost-Effectiveness of a Demand Creation Intervention to Increase Uptake of Voluntary Medical Male Circumcision in Tanzania: Spending More to Spend Less.

Sergio Torres-Rueda, Mwita Wambura, Helen A Weiss, Marya Plotkin, Katharine Kripke, Joseph Chilongani, Hally Mahler, Evodius Kuringe, Maende Makokha, Augustino Hellar and 11 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sergio Torres-RuedaDepartment of Global Health and Development, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Mwita WamburaNational Institute for Medical Research (NIMR), Mwanza, Tanzania.
Helen A WeissMRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Marya PlotkinJhpiego Tanzania, Dar es Salaam, Tanzania.
Katharine KripkeAvenir Health, Project SOAR, Washington, DC.
Joseph ChilonganiNational Institute for Medical Research (NIMR), Mwanza, Tanzania.
Hally MahlerJhpiego Tanzania, Dar es Salaam, Tanzania.
Evodius KuringeNational Institute for Medical Research (NIMR), Mwanza, Tanzania.
Maende MakokhaJhpiego Tanzania, Dar es Salaam, Tanzania.
Augustino HellarJhpiego Tanzania, Dar es Salaam, Tanzania.
Carl SchutteStrategic Development Consultants, Durban, South Africa.
Kokuhumbya J KazauraCenters for Disease Control and Prevention, Center for Global Health, Division of Global HIV & TB, Dar es Salaam, Tanzania.
Daimon SimbeyeCenters for Disease Control and Prevention, Center for Global Health, Division of Global HIV & TB, Dar es Salaam, Tanzania.
Gerry MshanaNational Institute for Medical Research (NIMR), Mwanza, Tanzania.
Natasha LarkeMRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Gissenge LijaMinistry of Health and Social Welfare, National AIDS Control Program, Dar es Salaam, Tanzania.
John ChangaluchaNational Institute for Medical Research (NIMR), Mwanza, Tanzania.
Anna VassallDepartment of Global Health and Development, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Richard HayesMRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Jonathan M GrundCenters for Disease Control and Prevention, Center for Global Health, Division of Global HIV & TB, Atlanta, GA.
Fern Terris-PrestholtDepartment of Global Health and Development, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Funding

CGH CDC HHS U01 GH000513Medical Research Council MR/K012126/1PEPFAR
6 · The paper itself

Abstract

backgroundAlthough voluntary medical male circumcision (VMMC) reduces the risk of HIV acquisition, demand for services is lower among men in most at-risk age groups (ages 20-34 years). A randomized controlled trial was conducted to assess the effectiveness of locally-tailored demand creation activities (including mass media, community mobilization, and targeted service delivery) in increasing uptake of campaign-delivered VMMC among men aged 20-34 years. We conducted an economic evaluation to understand the intervention's cost and cost-effectiveness.

settingTanzania (Njombe and Tabora regions).

methodsCost data were collected on surgery, demand creation activities, and monitoring and supervision related to VMMC implementation across clusters in both trial arms, as well as start-up activities for the intervention arms. The Decision Makers' Program Planning Tool was used to estimate the number of HIV infections averted and related cost savings, given the total VMMCs per cluster. Disability-adjusted life years were calculated and used to estimate incremental cost-effectiveness ratios.

resultsClient load was higher in the intervention arms than in the control arms: 4394 vs. 2901 in Tabora and 1797 vs. 1025 in Njombe, respectively. Despite additional costs of tailored demand creation, demand increased more than proportionally: mean costs per VMMC in the intervention arms were $62 in Tabora and $130 in Njombe, and in the control arms $70 and $191, respectively. More infections were averted in the intervention arm than in the control arm in Tabora (123 vs. 67, respectively) and in Njombe (164 vs. 102, respectively). The intervention dominated the control because it was both less costly and more effective. Cost savings were observed in both regions stemming from the antiretroviral treatment costs averted as a result of the VMMCs performed.

conclusionsSpending more to address local preferences as a way to increase uptake of VMMC can be cost-saving.

Indexed as

Circumcision, MaleCost-Benefit AnalysisAdultHumansMaleTanzaniaYoung Adult

Identifiers

PMID29557854
PMCPMC6012046

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.